
NCBI . NLM . NIH . GOV {
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Title[redir]:
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells - PMC
Description:
Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane phospholipid. We found that rotenone, staurosporine, ...
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Keywords {🔍}
doi, fig, mitochondrial, supplementary, mitophagy, mitochondria, pubmed, google, scholar, pmc, cells, article, free, autophagy, rotenone, neurons, protein, cell, omm, primary, shsyy, cardiolipin, parkin, data, proteins, imm, recognition, analysis, ohda, membrane, knockdown, table, nihmssupplementtif, tif, journal, increased, binding, surface, molecular, effects, cortical, important, response, beclin, phospholipid, predicted, elicited, gfplc, experiments, treated,
Topics {✒️}
protonophores carbonyl cyanide-p-trifluoromethoxyphenylhydrazone interferon-γ-induced mycobacterial clearance n-terminal α-helices abolished immunity-related gtpase irgm7 sterically-constrained head group phosphorylated erk/map kinases pl nmol/mg protein cl-modulating rnai treatments n-terminal α-helices parkin-expressing hela cells3 pmc beta search apoptotic jurkat cells--existence prevent autophagosome-lysosome fusion13 parkin-expressing-hela cells parkin-expressing hela cells include n-terminal residues voltage-dependent anion channels sh-sy5y neuroblastoma cells c2 membrane-binding domain cell-autonomous immunity functions human sh-sy5y cells transmembrane potential-independent dye gfp-lc3 puncta colocalizing autophagy-promoting kinase ampk ubiquitin-interacting protein p62 sh-sy5y cells treated sh-sy5y cells transfected nucleoside diphosphate kinase cardiolipin deficiency leads gfp-lc3 puncta formation lc-ms analysis demonstrated coarse-grained modeling mcherry-tagged p62/sqsmt1 diminished rotenone-induced mitophagy cl-binding regions predicted gfp-lc3 puncta elicited cccp-treated hela cells maintain cellular homeostasis top-ranked conformation gfp-lc3 mitochondrial colocalization cardiolipin-binding sites important individual molecular species amino acids interacting mitophagy-inducing sublethal rotenone mitochondrial-autophagosome adaptor proteins amino acids forming n-terminal domain 6-hydroxydopamine-treated neuronal cells lc3 recruit p62/sqstm1 n-terminal truncation
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Analytics and Tracking {📊}
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