
NCBI . NLM . NIH . GOV {
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Title[redir]:
Drugs or diet? – Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs - PMC
Description:
Free fatty acids (FFAs) are metabolic intermediates that may be obtained through the diet, synthesized endogenously, or produced via fermentation of carbohydrates by gut microbiota. In addition to serving as an important source of energy, FFAs are ...
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Keywords {🔍}
doi, ffa, pubmed, google, scholar, receptor, fatty, free, receptors, gpr, acid, effects, secretion, insulin, pmc, article, acids, gut, metabolic, cells, mice, inflammatory, studies, family, levels, human, diabetes, microbiota, dietary, glucose, fas, ligands, diet, therapeutic, activation, cell, agonists, development, hudson, treatment, role, pharmacol, lcfas, pancreatic, function, scfa, expression, gsis, beneficial, inflammation,
Topics {✒️}
glucose-dependent insulinotropic peptide peroxisome proliferator-activated receptors irritable bowel disease short-chain fatty-acid binding fatty-acid-stimulated insulin secretion conjugated linoleic acid long-chain fatty acid medium-chain fatty acids fatty acid-dependent step conjugated linoleic acids g-protein-coupled receptor ffar2 short-chain fatty acids free fatty acid mitochondrial/cytochrome c-dependent pathway increased peptide yy glucose-stimulated insulin secretion histone-deacetylase activity linoleic acid results medium-chain fas hdac inhibitors g-protein-coupled receptor 40 histone deacetylase peptide yy fatty acid terminology protein-coupled receptor ffa1/gpr40 fatty acid stimulation protein-coupled receptor list palmitate-induced β-cell apoptosis protein–independent β-arrestin signalling free fatty acids gi/o-coupled signalling pathways protein-coupled receptor gpr40 protein-coupled receptor gpr84 protein-coupled receptor ffa2 α-linolenic acid high-fat diet-induced obesity gpr40-induced insulin secretion bowel function cck secretion ffa2 long-term lcfa exposure long-chain fas β-arrestin-2 long isoform pmc beta search palmitate-induced er stress short-chain fas nit-1 β-cell line omega-3 fatty acids long-term lcfa treatment β–arrestin-biased ffa4 ligands negative long-term effects
Questions {❓}
- Could the quality of dietary fat, and not just its quantity, be related to risk of obesity?
- Drugs or diet?
- Gastrointestinal regulation of food intake: do gut motility, enteric nerves and entero-hormones play together?
- Lipid receptors and islet function: therapeutic implications?
- Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded?
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