
NCBI . NLM . NIH . GOV {
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Title[redir]:
Targeting Stromal Androgen Receptor Suppresses Prolactin-Driven Benign Prostatic Hyperplasia (BPH) - PMC
Description:
Stromal-epithelial interaction plays a pivotal role to mediate the normal prostate growth, the pathogenesis of benign prostatic hyperplasia (BPH), and prostate cancer development. Until now, the stromal androgen receptor (AR) functions in the BPH ...
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Keywords {🔍}
stromal, cells, mice, prostate, cell, figure, growth, bph, wtarpbprl, pubmed, google, scholar, doi, panel, epithelial, prl, pbprl, pshtert, mouse, human, stat, prostatic, darkopbprl, benign, hyperplasia, expression, fibromuscular, staining, treatment, bphprlr, receptor, hyperplastic, ascj, gmcsf, data, dlps, pmc, development, hprl, uroflow, compared, article, signals, quantification, androgen, factor, bladder, found, proliferation, signaling,
Topics {✒️}
granulocyte-colony stimulating factor glyceraldehyde-3-phosphate dehydrogenase smooth muscle α-actin quantitative real-time pcr prl/prlr-gm-csf/gm-csfr-stat3 stromal gm-csf/gm-csfr-stat3-ar extracellular matrix accumulation epithelial marker e-cad extracellular matrix fibroblast growth factor epithelial-mesenchymal transition e-cadherin smooth muscle cells e-cad mesenchymal markers n-cad gm-csf-mediated signaling activation anti-gm-csf neutralizing antibodies modulate gm-csf-stat3 signal g-csf receptor dorsolateral prostate lobes dimethylsulfoxide detect gm-csf receptor activated stat3 t-cell growth factor neutralizing gm-csf antibody prl/prlr-stat5 signal cascade 50 ng/ml gm-csf 10 ng/ml gm-csf dorsolateral prostate q-pcr analysis sustaining signal transducer intracellular gm-csf signaling mice-bearing pb-prl tg gm-csf-stat3 pathways gm-csf-stat3 signaling tgf-β-mediated downstream signals 3β-hydroxysteroid dehydrogenase uroflow obstructed-wt-ar/pb-prl gm-csfr generate wt-ar/pb-prl littermate wt-ar/pb-prl q-pcr epithelial growth factor growth factor array stat signal transducer n-cadherin g-csf downstream prl/prlr signal siar/stat3 shrna pshtert
Questions {❓}
- Could inflammation be a key component in the progression of benign prostatic hyperplasia?
- Does intraprostatic inflammation have a role in the pathogenesis and progression of benign prostatic hyperplasia?
- Evaluation of prostatitis in autopsied prostates—is chronic inflammation more associated with benign prostatic hyperplasia or cancer?
- Human benign prostatic hyperplasia: a stromal disease?
- [Benign prostatic hyperplasia—the outcome of age-induced alteration of androgen-estrogen balance?
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