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Title[redir]:
Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis - PMC
Description:
CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to increased cardiovascular complications, but the mechanisms linking Epo-dependent anemia and fibrosis remain unclear. Here, we show that the cellular phenotype of ...
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Keywords {🔍}
reps, cells, greps, figure, renal, kidneys, google, scholar, doi, pubmed, mice, epogfp, expression, fibrosis, uuo, signaling, kidney, day, epoproducing, myofibroblasts, epo, performed, pmc, anemia, nfκb, inflammatory, article, analyses, epocre, isam, gene, treatment, clip, free, αsma, group, signals, cell, potential, phenotypic, total, erythropoietin, supplemental, mrna, uuotreated, clipr, data, days, realtime, pcr,
Topics {✒️}
tgf-beta1/smad3 signaling protects tgepo3′-rescued epogfp/gfp mouse—designated 3′-enhancer-driven epo-expressing transgene nf-κb-driven renal inflammation specific pathogen-free facility epo-cre lineage-labeled cells g-rep–derived myofibroblasts contribute canonical nf-kappab activity org/lookup/suppl/doi unilateral ureteral obstruction αsma-positive epo-cre cells pmc beta search nfκb-mediated repressive regulation short-term pathologic insults tgf-β/smads limited epo-producing ability real-time pcr analyses high-throughput cre reporting lps-induced epo-gfp repression streptavidin-conjugated magnetic beads anti-inflammatory drug accelerates real-time pcr analysis normal epo-producing potential gfp-negative interstitial cells reverse epo-deficient anemia myofibroblast-transformed reps recover restoring myofibroblast-transformed reps renal epo-producing cells epo-cre cells recapitulated replaces baff-receptor signals renal erythropoietin-producing cells pmc copyright notice epo-gfp protein allowed recovering g-reps originated osmium-positive angular cells previous epo-producing cells ubiquitin-dependent degradation contributes supplementary materials included express cre enzyme characteristic juxta-medullary distribution homozygous r26-ikk2ca mice homozygous epo gfp-knock epo-gfp transcript level epo-gfp mrna levels uuo-induced renal fibrosis supplemental material online biotinylated anti-cd45 antibody myofibroblast-transformed g-reps epithelial-mesenchymal-myofibroblast transition ikk2ca-overexpressed reps changed
Questions {❓}
- Kriz W, Kaissling B, Le Hir M: Epithelial-mesenchymal transition (EMT) in kidney fibrosis: Fact or fantasy?
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