
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mapping cis- and trans-regulatory effects across multiple tissues in twins - PMC
Description:
Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many eQTL studies typically in single tissues from unrelated individuals. Here, we present a comprehensive ...
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Keywords {🔍}
doi, expression, gene, adipose, tissue, skin, google, scholar, pubmed, lcl, genetic, pmc, transcripts, analysis, supplementary, tissues, twin, article, common, data, effect, effects, free, heritability, cis, table, variants, proportion, snps, multiple, replication, fig, genet, genomewide, sample, samples, study, ciseqtl, variance, eqtl, association, studies, total, average, snp, mapping, disease, individuals, pairs, previously,
Topics {✒️}
combined ceu+yri+asn panels multiple disease-targeted cell-types low frequency/rare cis-variants large-scale cis-eqtl mapping large-scale multi-tissue design cis-hits tested/total hits trans-hits tested/total hits photo-protected area adjacent genome-wide regulatory behavior large-scale transcriptional profiling represent tissue-independent cis-heritability anti-viral expression network pmc beta search uk/resources/software/genevar/ genome-wide association analysis genome-wide eqtl associations log2-transformed expression signals genome-wide association study trans-variants regulating expression genome-wide association studies haseman-elston regression method tissue-dependent biological consequences genome-wide eqtl analysis family-based association tests linear mixed-effects models ampk-related kinase nuak1 cell type-dependent manner trans-acting locus regulates multiple trans-variants acting variance-component model adjusting linear mixed-effects model cell-type heterogeneity expected low p-values beneath identified cis-regulatory effects immunity-related gwas signals multi-gene regulators predominantly common cis-variants increases single trans-loci identified standard cis-eqtl analysis tissue-dependent manner similar post-qc expression profiles [google scholar] 38 [google scholar] 40 common cis-eqtl effects standard cis-eqtl analyses cis-eqtl gwas loci cis-eqtl mapping approach inverse variance-covariance matrix rare regulatory variants estimated narrow-sense heritability
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- Are twins and singletons comparable?
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