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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, cancer, scholar, pubmed, google, cells, immune, lactic, acid, metabolism, tumour, cancers, energy, cell, glycolysis, pmc, aerobic, article, microenvironment, free, response, lactate, tumor, metabolic, altered, anticancer, hypoxic, conditions, inhibition, immunosuppressive, pathways, warburg, effect, glucose, role, glutaminolysis, normal, increased, lead, function, nlm, development, pyruvate, oxidative, angiogenesis, growth, critical, phosphorylation, production, progression,

Topics {✒️}

tumour-blood-vessel-lining cells jnk/c-jun activation immuno-uncompromised models required acid-resistant phenotypes exhibiting pmc beta search sodium–proton exchanger family lactic acid-induced acidification cancer-generated lactic acid lactic acid-producing metabolisms tumor-secreted lactic acid ph-dependent antitumor activity cytotoxic t-lymphocytes play anti-cancer immune response pmc copyright notice immune destruction—lactic acid acidified tumour micro-environment murine tumour-infiltrating lymphocytes suppress t-cell function slightly acidic micro-environment acidic tumour micro-environment cancer micro-environment suppressing promotes unconstrained proliferation cancer growth-promoting angiogenesis t-cell function publisher site pdf lactic acid generated suppresses cycling hypoxia cytotoxic immune response innovative scholar award increases antitumor immunoreactivity murine tumor-infiltrating anti-cancer activity improved cancer therapy license information pmcid normal physiological processes anti-glycolytic activity reactive oxygen species biochem cell biol t-cell responses anti-cancer treatments markedly promote angiogenesis tumor immune escape tumor cell metabolism endogenous immune response altered glucose/glutamine metabolism biochim biophys acta page abstract introduction �reprogrammed energy metabolism reprogrammed energy metabolism effector t-cells

Questions {❓}

• Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
• Immune surveillance of human cancer: if the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?
• Metabolic acidosis in patients with sepsis: epiphenomenon or part of the pathophysiology?
• Why do cancers have high aerobic glycolysis?
• Why do cancers opt for altered energy metabolism?

Social Networks {👍}(6)

• https://twitter.com/ncbi
• https://www.facebook.com/ncbi.nlm
• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

External Links {🔗}(115)

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