
NCBI . NLM . NIH . GOV {
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Title[redir]:
RARα2 expression confers myeloma stem cell features - PMC
Description:
RARα2 activates Wnt and hedgehog pathways in maintaining myeloma stem cell features and drug resistance.
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Keywords {🔍}
cells, rarα, doi, cell, expression, myeloma, stem, figure, pubmed, google, scholar, ocimy, wnt, arp, increased, pmc, article, lines, signaling, drug, resistance, genes, cancer, free, significantly, showed, compared, nanog, blood, ark, multiple, tgm, kms, overexpressing, cay, control, pathways, cyclopamine, atra, pathway, gli, levels, gene, abcc, treated, tcf, performed, western, βcatenin, higher,
Topics {✒️}
affymetrix hugene-1_0-st-v1 microarray cd19−/cd45low/−/cd38high/cd138+ cells cytoplasmic light chain-restricted rarα2-overexpressing oci-my5 cells pmc beta search survives myelo-ablative therapy rarα2 induces drug-resistance kaplan-meier curves show alternative nf-kappab pathways real time-pcr revealed chromatin-mediated protein interaction nuclear/cytosol fractionation kit beta-catenin/lef-1 pathway page charge payment beta-catenin regulates expression real-time pcr showed real-time pcr shows abc transporter members rarα2-induced drug resistance blood web site oci-my5 overexpressing rarα2 rarα2 overexpressing oci-my5 oci-my5 cells contained western-blot results showed rarα2-overexpressing myeloma cells rarα2-overexpressing mm cells rarα2-positive myeloma cells western-blot assays showed stem cell features performed real-time pcr supplementary materials included oci-my5 cell lysate oci-my5 cells compared drug-sensitive myeloma cells sp/κ+ mm cells sp/κ+ mm cells endogenous nuclear β-catenin rarα2-overexpressing cells arp1 key features embryonic stem cell rarα2-oe oci-my5 methods cell lines drug-resistance genes abcc3 dana-farber group found cell stem cell multidrug-resistance assays colony formation assay colorectal cancer cells beta-catenin signaling efflux pump induced
Questions {❓}
- Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured?
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