
NCBI . NLM . NIH . GOV {
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Title[redir]:
mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis - PMC
Description:
The mammalian target of rapamycin (mTOR)-pathway serves as a key sensor of cellular-energetic state, and functions to maintain tissue homeostasis. Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) function and is associated ...
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Keywords {🔍}
mice, cells, raptor, doi, mtorc, figure, cell, mxcre, raptorflfl, deletion, pubmed, google, scholar, data, hsc, loss, stem, shown, hematopoietic, pmc, post, mtor, pipc, hspc, pipctreated, article, weeks, required, free, activity, rictor, pten, levels, flfl, leukemogenesis, transplanted, function, lsk, alleles, assessed, chimerism, functions, regeneration, survival, figures, raptornull, hematopoiesis, performed, vivo, spleen,
Topics {✒️}
lt-hsc-enriched flt3−cd34−lsk subset lin− pi− sca-1−c-kit+[lk] mature lin−sca−1−c-kit−cells cd48/cd150/cd34/flt3/lsk subsets cd48+cd150+-flt3−cd34+ lsk cells cd48−cd150+flt3−cd34−-lt-hsc lin− pi− sca-1−c-kit[ splenic lin−c-kit+-sca-1− lsk-cd48−cd150+ facs-sorted cells 10%fbs/imdm/50µg/ml verapamil fixed/permeablized lsk-gated events hspc-enriched flt3-lsk cells b220+igm−cd43+ prob cells mac-1+gr-1mid/lo monocytes splenic lsk-cd48−cd150+ cells scf-treated lin-pi-cells interferon-inducible transgenic-mx1cre mice t-acute lymphoblastic leukemia/lymphoma pe-cy7-conjugated antibody mac-1+gr-1mid/lo scf-treated lsk-gated cells sheep anti-rat dynabeads flt3+cd34+lsk sorted lin−pi− cells ubc-cre-er compound mice scf-stimulated raptor-null lsk lsk-cd48−cd150+ cells long-term lymphohematoopietic reconstitution facs-sorted lsk populations labeled lsk-cd48−cd150+ potent anti-leukemic activity pmc beta search pten/raptor double knockouts gene-set enrichment analysis raptor-deleted pten-homozygous chimerism raptor-deleted lsk subsets tsc-mtor maintains quiescence splenic b220+igmloigd+ cells raptor-deleted lt-hscs short-term hsc p53/p19arf/p16ink4a axis c-kit signaling facs-sorted cell populations ncbi gene-expression omnibus indicating cell-type specificity produced ptenfl/fl mice 200 facs-sorted lt-hsc generating compound raptorfl/fl scaffolding/substrate-guiding proteins retained deleted-raptor alleles
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- How much money does https://www.nih.gov/ make?
- How much money does https://www.hhs.gov/ generate?
- Profit of https://www.usa.gov/
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi