
NCBI . NLM . NIH . GOV {
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Title[redir]:
The importance of intrinsic disorder for protein phosphorylation - PMC
Description:
Reversible protein phosphorylation provides a major regulatory mechanism in eukaryotic cells. Due to the high variability of amino acid residues flanking a relatively limited number of experimentally identified phosphorylation sites, reliable ...
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Keywords {๐}
phosphorylation, sites, protein, data, residues, google, scholar, set, pubmed, regions, doi, amino, proteins, disorder, disordered, predictor, accuracy, sets, acid, sequence, site, ordered, positive, negative, class, kinase, table, prediction, kinases, features, examples, serine, acids, predicted, estimated, enriched, fig, high, structure, npsites, depleted, number, disphos, observed, tyrosine, phosphorylated, swissprot, predictors, noise, pmc,
Topics {โ๏ธ}
v-cyclin-cdk6-mediated phosphorylation elsevier/north-holland biomedical press nsf grants nsf-cse-iis-9711532 maximum-likelihood technique suited binding-dependent disorder-order transition camp-dependent protein kinase mass spectrometry-based technologies cgmp-dependent protein kinases pmc beta search combining nearest-neighbor algorithms p14-arf-binding regions disorder-promoting amino acids order-promoting amino acids phosphorylation sites [st]-x-[rk] protein structure-function paradigm neural-network based predictors modifying pattern-matching methods cyclin-dependent kinases positive free energy amino acids surrounding nucleic acids res web-based tool large-scale phosphorylation patterns motif-based service scansite disorder-enhanced phosphorylation predictor comparative sequence/structure analysis large-scale conformational change disorderโdisordered regions characterized significant position-specific residues significant position-specific features anti-apoptotic potential discussion predictor optimization extensive hydrogen bonding nucleic acids research oxford university press amino acid compositions examined amino acids overlook amino acids biologically relevant functions neutral amino acids smaller fixed number neural network models short sequence motifs including kinase names amino acid sequences intrinsically disordered regions undergo reversible phosphorylation united states government single long string k-nearest neighbors
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