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Keywords {🔍}

brca, cells, nrf, levels, pubmed, google, scholar, ros, fig, doi, cell, cancer, pmecs, breast, expression, mice, mammary, keap, pmc, mouse, data, antioxidant, article, protein, mrna, free, tumor, human, oxidative, control, stress, nqo, vivo, kbff, tumors, dna, treated, kbfflucf, survival, analysis, sirna, gene, bso, klucf, outgrowths, shrna, staining, commad, brcadeficient, nature,

Topics {✒️}

l-buthionine-sulfoximine propidium iodide empty vector reactive oxygen species frequently estrogen receptor pmec outgrowths org/cgi/content/full/jem doxycycline luciferase phenol red–free media masc-enriched basal cells cul3-based e3 ligase 1puro lentiviral vector breast epithelial cells brca-mutated breast cancers human brca1-mutated basal cell cycle–dependent manner cell cycle-dependent manner undergone cre-mediated recombination bso-treated comma-1d cells hmec isolation cy2-conjugated anti–rabbit high-throughput cre reporting pmc beta search k6a-driven cre recombinase oxidation-damaged base 8-oxodg hormone-responsive breast cancer mammary stem cells nrf2-dependent signaling induced dox-inducible brca1 shrna atm-dependent checkpoint response brca1-deficient primary mecs cre-mediated deleted allele nrf2-mediated antioxidant pathway brca1-mutated tumors retain brca1-mutated tumor cells nrf2-dependent antioxidant genes nrf2-mediated antioxidant response 6 glacial acetic/chloroform/ethanol p21/cdkn1a mrna levels pmc copyright notice splice variant brca1-delta11b nrf2-dependent antioxidant program nf-e2–related factor 2 anti–mouse brca1 ab single stem cell luc-expressing transgenic mice cy3-conjugated anti–mouse brca1-proficient breast cancers ha–79egte nrf2 mutant

Questions {❓}

• Detoxification: a novel function of BRCA1 in tumor suppression?
• Nrf2: friend or foe for chemoprevention?

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• https://doi.org/10.1182/blood-2011-07-367755 income
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