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Title[redir]:
The JAK-STAT pathway in hypertrophic stress signaling and genomic stress response - PMC
Description:
The JAK-STAT signaling pathway plays a central role in transducing stress and growth signals in the hypertrophic heart. Unlike most signal transducers, JAKs and STATs signal in a number of different ways, both within the JAK-STAT pathway and in ...
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Keywords {🔍}
doi, pubmed, google, scholar, signaling, cardiac, pathway, receptor, hypertrophy, jakstat, stat, hypertrophic, gene, transcription, jak, kinase, cardiomyocytes, activation, cell, receptors, response, ang, signal, genes, heart, pathways, stress, pmc, rna, protein, mol, signals, cells, transcriptional, role, angiotensin, factor, activated, free, article, res, kinases, expression, cdk, cardiol, myocytes, biol, clp, activate, complex,
Topics {✒️}
ras/mek/erk/p38 pathway leading mek/erk/p90 cascade leading canonical il-6r/gp130-jak-stat pathway chromatin-modifying proteins p300/cbp stromal cell-derived factor-1α leukemia inhibitory factor g-protein linked receptors clp-1-p-tefb regulatory complex il6-α/gp130 receptor plays il-6rα/gp130 receptor resulting p-tefb de-represses cdk9 intracellular renin-angiotensin system αb-crystallin introduction il-6/sil-6r complex associates ip3 kinase scaffolding/docking protein gab1 il6-α/gp130 type receptors cyclin dependent kinase phospho-jak2 kinase high clp-1 inhibits p-tefb full-length rna transcripts chaperone alphab-crystallin cdk9-cyclin t1 complexes renin-angiotensin system protein-coupled receptors cdk9-cyclin t1 complex interleukin 6-inducible cdk9 pmc beta search calcineurin-nfat signaling activated de-repress p-tefb ifnγ-activated sequences mediates stat3-p-tefb complex jak2 kinase cross-phosphorylation interleukin 6-related cytokines clp-1-p-tefb model canonical jak-stat pathway t-type calcium channels pressure overload-induced activation interleukin-6-type cytokine signalling jak-stat pathway differs jak-stat pathway broadens mechanical stress-induced hypertrophy involves stat-dependent activation ras-related genes human hexim1 gene heat shock protein ang ii-il-6 signaling jak-stat signaling contributes 1 receptor-jak-stat pathway cardiac lineage protein-1
Questions {❓}
- Jak2 tyrosine kinase: a true jak of all trades?
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