
NCBI . NLM . NIH . GOV {
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Title[redir]:
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells - PMC
Description:
In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and influence mRNA translation, thereby regulating the self-renewal of ...
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Keywords {🔍}
doi, pubmed, google, scholar, lin, cell, pmc, stem, article, free, cells, lina, linab, cancer, selfrenewal, human, linb, microrna, regulate, elegans, expression, mammalian, metabolism, escs, development, nature, reprogramming, mouse, rna, science, tissue, genes, differentiation, dev, biol, growth, translation, zhu, regulates, wang, overexpression, adult, embryonic, directly, pluripotent, studies, targets, factors, micrornas, moss,
Topics {✒️}
inflammation-/stress-responsive nf-κb cre-er-driven mouse models long-term adult hscs single-cell rna-seq analysis retinoic acid-induced differentiation genome-wide rna-immunoprecipitation studies telomeric g-strand tails pmc beta search long-lived mouse strains rna-induced silencing complex nf-κb transactivate lin28b genome-wide approach reveals x-ray crystallography studies reverts myc-induced growth peripheral t-cell lymphoma nuclear protein-protein complex degrade oligo-uridylated pre single-cell expression analyses neural stem-cell commitment primordial germ-cell development insulin-pi3k-mtor pathway lin-4 homolog mir-125a/ genome-wide studies reveal impaired t-cell development genome-wide association study expect oligo-uridylated pre rna-processing mechanisms relate leukaemia-initiating cells post-transcriptional rna processing tumor-initiating cells fetal hematopoietic stem repress lin-28 post-transcriptionally upregulate insulin/pi3k signaling inhibit neuronal differentiation aging telomerase-deficient mice rna-binding cofactor dgcr8 thr-gly-sam pathway rna-binding protein lin28 mll-fusion/myc/lin-28 neural crest progenitors primitive neural tissue nuclear receptor signaling stem cell exhaustion nuclear receptor nr5a2 regulate stem/progenitor cell bhat-nakshatri embryonic stem cells promising universal factor regulatory signals upstream tumorigenic melanoma cells
Questions {❓}
- And what conditions or pathways regulate the mechanism of Lin28a or Lin28b within the nucleolus, the cytoplasm, and P-bodies?
- But is Lin28 also required for pluripotency?
- But what else could Lin28a/b be doing in the nucleus?
- Could Lin28 show similar potential in reengineering adult human cells (Figure 3)?
- Do pluripotent stem cells then require Lin28a/b for indefinite self-renewal?
- Healthy aging: is smaller better?
- If Lin28a/b can enhance self-renewal, what effects would it exert on adult tissue repair in vivo?
- The central role of the Lin28/let-7 bistable switch in governing stem cell self-renewal raises the provocative question: what signaling pathways converge upstream to regulate the switch?
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- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=An%20epigenetic%20switch%20involving%20NF-kappaB,%20Lin28,%20Let-7%20microRNA,%20and%20IL6%20links%20inflammation%20to%20cell%20transformation&author=D%20Iliopoulos&author=Ha%20Hirsch&author=K%20Struhl&volume=139&publication_year=2009&pages=693-706&pmid=19878981&doi=10.1016/j.cell.2009.10.014& generate monthly?
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- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=Imp2%20controls%20oxidative%20phosphorylation%20and%20is%20crucial%20for%20preserving%20glioblastoma%20cancer%20stem%20cells&author=M%20Janiszewska&author=ML%20Suva&author=N%20Riggi&author=RH%20Houtkooper&author=I%20Radovanovic&volume=26&publication_year=2012&pages=1926-1944&pmid=22899010&doi=10.1101/gad.188292.112& each month?
- Check the income stats for https://doi.org/10.1016/j.ccr.2012.08.028
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet&title=Expression%20of%20TERT%20in%20early%20premalignant%20lesions%20and%20a%20subset%20of%20cells%20in%20normal%20tissues&author=KA%20Kolquist&author=LW%20Ellisen&author=CM%20Counter&author=M%20Meyerson&author=LK%20Tan&volume=19&publication_year=1998&pages=182-186&pmid=9620778&doi=10.1038/554&
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