
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Relationship between the proteasomal system and autophagy - PMC
Description:
Two major pathways degrade most cellular proteins in eukaryotic cells: the ubiquitin–proteasome system (UPS), which usually degrades the majority of proteins, and autophagy, primarily responsible for the degradation of most long-lived or aggregated ...
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Keywords {🔍}
doi, autophagy, proteins, google, scholar, pubmed, protein, degradation, cell, proteasome, ubiquitin, pmc, free, atg, article, pathways, biol, cells, complex, autophagic, cellular, degraded, system, ups, stress, pathway, mol, proteasomal, substrate, activity, including, amino, membrane, degradative, response, process, addition, involved, formation, diseases, energy, mechanisms, role, ulk, disease, cancer, autophagosome, regulation, control, structure,
Topics {✒️}
dose-limiting systemic side-effects n-terminal α-helix surface 5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone phosphoinositide-3-kinase related kinase pmc beta search n-terminal phox/bem1 pressure-overload mouse hearts serine-threonine kinase tor n-terminal amino acid n-terminal amino acids short-lived proteasome-specific substrates γ-aminobutyrate acid receptor polyglutamine-induced lc3 conversion wd-repeat protein interacting carboxy-terminal amino acid c-terminal buz domain bind n-terminal sequences n-end dependent degradation y-box-binding protein 1 n-end rule pathway ypt/rab effector complex proteasomal inhibition-induced neurotoxicity mutant aggregate-prone proteins free ubiquitin regeneration crescent-shaped structure called canonical ubiquitin-based signals undergo ubiquitin-independent degradation long k63-linked chains license information pmcid post-translational protein modifications k63-linked polyubiquitinated chains recruit ubiquitin-conjugating enzymes degrade aggregate-prone proteins processive e2/e3 enzymes stress-induced unfolded proteins primary detection device front-line detectors constituted ca++-free calmodulin amp-activated protein kinase annu rev biochem integrative program concerns lc3 recruit p62/sqstm1 multi-step process regulated nat cell biol �n-end” rule n-end rule nuclear factor kappab1 amino-terminal end n-terminal methionine damage-regulated autophagy modulator
Questions {❓}
- Canonical and non-canonical autophagy: variations on a common theme of self-eating?
- Mitochondrial clearance by autophagy in developing erythrocytes: clearly important, but just how much so?
- What determines the specificity and outcomes of ubiquitin signaling?
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