
NCBI . NLM . NIH . GOV {
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Title[redir]:
High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis - PMC
Description:
Using the Immunochip custom single nucleotide polymorphism (SNP) array, designed for dense genotyping of 186 genome wide association study (GWAS) confirmed loci we analysed 11,475 rheumatoid arthritis cases of European ancestry and 15,870 controls ...
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Keywords {🔍}
loci, rheumatoid, arthritis, doi, snps, association, snp, immunochip, data, table, supplementary, analysis, acpa, rsb, intron, eqtl, disease, samples, pubmed, pmc, gwas, google, scholar, previously, article, cases, independent, genet, identified, positive, effect, metaanalysis, allele, risk, free, study, observed, collections, nat, confirmed, controls, gene, region, rsa, locus, effects, associations, included, performed, datasets,
Topics {✒️}
inverse-variance weighted meta-analysis inverse-variance meta-analysis assuming distinct immune cell-types16 anti-citrillunated peptide antibodies identify rheumatoid-arthritis-susceptibility loci x-linked gene expression pmc beta search minimise inter-marker ld org/mpg/grail/grail snp&seq technology platform genome-wide significance level genome-wide association studies acpa-negative rheumatoid arthritis imputation-driven meta-analysis study-wide significance threshold haplotype specific effects hla-drb1 peptide sequence swedish research council meta-analysis identifies genome-wide levels rheumatoid arthritis susceptibility immunochip meta-analysis resulted samples identified post-genotyping genome-wide significance genome wide significance population-based linkage analyses dec2006 pubmed datasets extensive manual review rheumatoid arthritis genetics rheumatoid arthritis associations dense genotyping identifies essential splice site amino acid change de bakker pi illumina ht12v3 platform illumina h8v2 platform illumina hap300k platform low statistical information seropositive rheumatoid arthritis collaborative meta-analysis united states government license information pmcid manifest file immuno_beadchip_11419691_b significant polymorphic nucleotide principal component analysis fine-mapping experiments systematic fine mapping shows high correlation previous meta-analysis poor quality assays
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