
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors - PMC
Description:
Approximately 15–30% of women diagnosed with ductal carcinoma in situ (DCIS) develop a subsequent tumor event within 10 years after surgical lumpectomy. To date, little is known about the molecular pathways that confer this differential risk for ...
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Keywords {🔍}
doi, cox, dcis, high, pubmed, google, scholar, expression, subsequent, cancer, tumor, tumors, cells, lesions, breast, women, figure, levels, basallike, protein, cell, invasive, low, mrna, cyclin, overexpression, pmc, prb, cellular, molecular, subtype, article, carcinoma, develop, risk, disease, free, stress, table, proliferation, signaling, data, response, situ, grade, microarray, samples, staining, ductal, gene,
Topics {✒️}
retinoblastoma-protein-dependent cell-cycle inhibition 1ng/ml tgf-β reduced recurrence-free survival oncogene-induced cell senescence--halting hpv e6/e7 proteins experimental procedures cells pmc beta search human papilloma virus16-e7 paraffin-embedded tumor samples high-grade dcis lesions high p16/high ki67 high-grade lesions demonstrate rb-mediated heterochromatin formation functional p16/rb signaling high cox-2/high ki67 dana-farber cancer institute recurrence-free survival quiescent cox-2-positive lesions compromised p16/rb signaling cox-2-induced growth arrest p16-dependent growth arrest wilcoxon/kruskal-wallis rank serum-free growth disease-free prognosis low er/pr expression oncogene-driven mitogenic signals cyclin d-cdk complexes er-negative restricted definition candidate anti-cancer barrier p16/rb signaling proliferate supplementary materials included rb/e2f pathway results hmec expressing hpv16-e7 rb-negative cells correlates mammary cell lines actively proliferating cells distinct cyclin-cdk complexes high nuclear grade prostate epithelial cells g1/s-regulatory proteins protective anti-proliferative response retinoblastoma protein induces showed elevated p16 p53-dependent cellular senescence initiate stress-induced overexpression primary tumour compared high-risk hpv tumour suppressor p16 pre-malignant lesions functional rb signaling
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