
NCBI . NLM . NIH . GOV {
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Title[redir]:
Otud7b controls noncanonical NF-κB activation via deubiquitination of TRAF3 - PMC
Description:
The noncanonical NF-κB pathway forms a major arm of NF-κB signaling that mediates important biological functions, including lymphoid organogenesis, B lymphocyte function, and cell growth and survival1-3. Activation of the noncanonical NF-κB pathway ...
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Keywords {🔍}
doi, otudb, traf, mice, fig, cells, nfκb, pubmed, google, scholar, otudbko, noncanonical, supplementary, pmc, signaling, activation, article, pathway, lymphoid, receptor, stimulated, free, mefs, immunol, assays, data, cell, ubiquitination, day, nature, bcell, expression, regulates, isolated, antibody, nfkappab, rodentium, ltβr, subjected, recruitment, immunity, ngml, nlm, deubiquitination, factor, intestinal, regulation, kinase, antibodies, ubiquitin,
Topics {✒️}
nf-kappab-inducing kinase regulates regulate tnf-induced nf-kappab alternative nf-kappab pathway otud7b controls signal-induced noncanonical nf-kappab pathway noncanonical nf-κb pathway noncanonical nf-κb signaling9 noncanonical nf-κb signals specific pathogen-free facility created site-directed mutagenesis noncanonical nf-kb pathway noncanonical nf-κb signaling cell-conditional traf3-ko mice regulating nf-κb activation nf-kappab-inducing kinase nf-κb-inducing kinase noncanonical nf-κb stimuli canonical nf-κb pathway regulating b-cell responses canonical nf-κb activation bone marrow-derived macrophages 32p-radiolabeled oligonucleotide probes nf-kb signaling pathway noncanonical nf-κb inducers b-cell adoptive transfer pmc beta search gene-specific primers listed noncanonical nf-κb regulation ubiquitin-dependent kinase tak1 control dna-binding factors producing glutathione-s-transferase conventional gene-targeting approach involves otud7b-mediated deubiquitination elevated host-defense ability cell-activating factor belonging serum np-specific antibodies anti-k11 ubiquitin antibody c57bl/6×129/sv genetic background chain-specific ubiquitin antibodies otud7b-ko mice displayed cd4 t-cell depletion noncanonical nf-κb adenoviral e1a proto-protein splenic b-cell purification otud7b-ko primary mefs otud7b-ko cells displayed purified traf3-ubiquitin conjugates b-cell proliferation assays generate age-matched wt antigen-stimulated antibody production
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