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Title[redir]:
MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma - PMC
Description:
Differences among cancer cells within a tumor are important in tumorigenesis and treatment resistance, yet no measure of intratumor heterogeneity is suitable for routine application. We developed a quantitative measure of intratumor genetic ...
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Keywords {🔍}
math, heterogeneity, doi, tumor, loci, hnscc, intratumor, mutations, tumors, cancer, mutated, pubmed, google, scholar, pmc, mutantallele, mutation, fractions, relation, values, cell, article, genetic, fig, measure, head, neck, disruptive, free, ngs, results, hpvnegative, status, data, supplementary, sequencing, distribution, cigarette, clinical, cna, human, outcomes, nlm, carcinoma, dna, center, wildtype, populations, median, number,
Topics {✒️}
genomic copy-number alterations analyze pre-selected markers single-molecule sequencing smoothes wilcoxon rank-sum tests pmc beta search mutant-allele fractions determined mutant-allele fractions corrected normal-cell numbers appears virus-related cancer epidemic low mutant-allele fractions genomic copy numbers squamous-cell carcinoma mutant-allele tumor heterogeneity oncogene-expressing human papillomavirus ngs exome-sequencing results high-fraction loci common versus wild-type tp53 tumor-specific mutated loci splice-site mutations pre-identified markers single-cell sequencing license information pmcid explicitly including information cancer genome atlas mutant-allele fractions van der riet single-cell analysis human papillomavirus-positive head genomically distinct subpopulations generating clonal subpopulations reported pcr results mutagenic risk factor clinically significant aspects final edited form amino-acid residue l3 binding domains kernel density estimates thick horizontal lines bivariate linear model fundamentally limit identification norman knight fund final citable form production process errors intra-glandular spread initial neoplastic clone radiation-induced senescence nguyen-tan pf intratumor genomic heterogeneity sequence-read errors genetic progression model
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- Intra-tumour heterogeneity: a looking glass for cancer?
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