
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells - PMC
Description:
The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non–small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of ...
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Keywords {🔍}
tumor, cells, circulating, egfr, patients, doi, mutation, del, mutations, cancer, lung, google, scholar, pubmed, detected, sarms, analysis, therapy, kinase, response, gefitinib, tyrosine, nonsmallcell, assay, inhibitors, dna, free, tumors, number, clinical, pmc, plasma, adeno, primary, sequencing, article, molecular, blood, resistance, detection, treatment, specimens, identified, activating, present, amplification, time, patient, med, allele,
Topics {✒️}
allele-specific polymerase-chain-reaction amplification cloned polymerase-chain-reaction small-cell lung cancer small-cell lung cancer small-cell lung cancers epithelial-cell adhesion molecule c-met proto-oncogene allele-specific sarms assay23 reduced progression-free survival decreased progression-free survival magnetic bead–conjugated antibodies essco–mgh research fund large-scale clinical trials high-performance liquid chromatography pmc beta search form covalent cross-links therapeutic decision-making points pmc copyright notice allele-specific sarms assay captured tumor-cell purity ideal/intact gefitinib trials genotype-directed clinical trials allele-specific sarms analysis t790m drug-resistance allele pretreatment tumor-biopsy specimens mutation-targeted cancer therapies drug-resistance mutation t790m t790m drug-resistance mutation original tumor-biopsy specimens combination targeted-therapy regimens treatment-induced genetic change secondary mutant alleles supplementary materials included full text med abstract background progression-free survival lung cancer offers license information pmcid egfr kinase domain confers drug resistance rare cell populations specific genetic lesions tyrosine kinase inhibitors human cancer genomes matched radiographic measurements free plasma dna circulating tumour cells transplex amplification kit natl cancer inst phase ii trial
Questions {❓}
- Circulating tumor cells in metastatic breast cancer — toward individualized treatment?
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