
NCBI . NLM . NIH . GOV {
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Title[redir]:
Aiolos promotes TH17 differentiation by directly silencing Il2 expression - PMC
Description:
CD4+ interleukin 17 (IL-17)-producing helper T cells (TH17 cells) are instrumental in the immune response to pathogens. However, an overactive TH17 response results in tissue inflammation and autoimmunity, and therefore it is important to identify ...
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Keywords {🔍}
cells, doi, differentiation, expression, aiolos, fig, aiolosdeficient, mice, ikzf, pubmed, google, scholar, wildtype, pmc, production, conditions, control, ahr, promoter, stat, article, transcription, data, free, naive, cell, vitro, analysis, activated, ifnγ, immunol, ikaros, development, vivo, differentiated, supplementary, thpolarizing, rag, antibody, results, factors, generation, family, regulatory, foxp, upregulation, nat, interleukin, helper, activation,
Topics {✒️}
naive cd4+cd25−cd62l+cd44lo aiolos-deficient cd4+cd25−cd45rbhi carrier-free recombinant il-12 electrophoretic mobility-shift assay transcription factor nf-κb aryl hydrocarbon receptor naive cd4+cd25−cd45rbhi haematopoietic cell-fate decisions pmc beta search double-stranded oligonucleotide composed intra-cellular cytokine staining putative stat3-responsive elements real-time pcr putative aiolos-binding site transforming growth factor-β1 enzyme-linked immunosorbent assay ifn-γ-producing th1 cells cd4+cd25+foxp3+ regulatory sex-matched rag2−/− mice genome-wide chip analyses pathogen-free facility cell-mediated intestinal inflammation magnetic bead–chromatin complexes high-affinity il-2 receptor stat-dependent cytokine signals transferred naive wild-type il-7rα-expressing cells putative ahr-binding sites th17 cell–intrinsic mechanism cd4+cd25−cd45rbhi isotype-matched control antibody target dna-binding sites il-6-dependent signaling events plate-bound anti-cd3 supplementary materials included naive aiolos-deficient cd4+ aiolos-deficient naive cd4+ transit-jurkat transfection reagent promote th17-type immunity12 il-17-producing cd4+ memory isotype-matched control antibodies ahr-specific ligand ficz wild-type donor cells immunized naive wild-type th17-polarizing conditions resulted recombination-activating gene 2 proliferative recall response th17-polarizing conditions produced putative target sequence t-helper-cell differentiation
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Analytics and Tracking {📊}
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Emails and Hosting {✉️}
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