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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

notch, cells, cell, pubmed, google, scholar, doi, endothelial, tip, signaling, vegf, dll, vascular, vegfr, angiogenesis, expression, stalk, pmc, sprouting, growth, vegfa, article, tumor, pathway, free, fig, ligand, development, jagged, formation, signalling, genes, gerhardt, mouse, factor, vessel, receptor, pathways, angiogenic, activation, dev, selection, gene, activity, mice, complex, behavior, expressed, levels, tipstalk,

Topics {✒️}

vecad-creert2/r26r/notch1fl/fl mice vecad-creert2/r26r/notch1floxed/floxed mice mosaic cre-lox-mediated recombination constitutively notch-signaling-active cells high-molecular-weight notch complex vegf-dll4/notch feedback loop initially considered endothelial-specific pmc beta search r26r cre-reporter allele contact-mediated “lateral inhibition” time-lapse confocal microscopy histone acetylase cbp/p300 lumen-forming stalk cell pro-angiogenic factor vegf tip/stalk cell selection initial oxygen-induced regression hfsp long-term fellowship tip/stalk selection model mediate tip–stalk selection endothelial-specific notch1 loss tip/stalk selection illustrated constitutive endothelium-specific expression wild-type mice treated arterial–endothelial cell fate cell-surface glycoproteins neuropilin1 wild-type host embryos tip/stalk cell concepts tip/stalk selection process evolutionarily conserved mechanism vegf-a-mediated induction promotes tumor growth notch-signaling-deficient cells placenta growth factor oxygen-induced ischemic retinopathy dll4-overexpressing endothelial cells wild-type embryonic stem cell-autonomous manner induces filopodia formation dll4/notch lateral inhibition vegf–notch signalling pathways including cell-surface receptors tip/stalk specification principle publisher site pdf agent-based computational model dll4-heterozygous es cells extracellular matrix-bound vegf inducible mosaic recombination pre-existing vessel stalk cell selection endothelial growth factors

Questions {❓}

• Are tip and stalk cells universal concepts applicable to all areas of angiogenesis?
• Notch signalling: Direct or what?
• One of the first questions that arise from the observation of different endothelial cell phenotypes in the vascular sprout is: How are these cellular phenotypes specified?

Social Networks {👍}(6)

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• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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• https://doi.org/10.1016/j.mvr.2007.06.006 income
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• See how much https://doi.org/10.1002/dvdy.21114 makes per month
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• Check the income stats for https://doi.org/10.1101/gad.12.15.2269
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=A%20histone%20deacetylase%20corepressor%20complex%20regulates%20the%20Notch%20signal%20transduction%20pathway&author=HY%20Kao&author=P%20Ordentlich&author=N%20Koyano-Nakagawa&author=Z%20Tang&author=M%20Downes&volume=12&publication_year=1998&pages=2269-2277&pmid=9694793&doi=10.1101/gad.12.15.2269& bring in?
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• How much does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=Notch%20signalling%20is%20essential%20for%20vascular%20morphogenesis%20in%20mice&author=LT%20Krebs&author=Y%20Xue&author=CR%20Norton&author=JR%20Shutter&author=M%20Maguire&volume=14&publication_year=2000&pages=1343-1352&pmid=10837027& make?
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• What's https://scholar.google.com/scholar_lookup?journal=Mech%20Dev&title=The%20novel%20Notch%20homologue%20mouse%20Notch%203%20lacks%20specific%20epidermal%20growth%20factor-repeats%20and%20is%20expressed%20in%20proliferating%20neuroepithelium&author=M%20Lardelli&author=J%20Dahlstrand&author=U%20Lendahl&volume=46&publication_year=1994&pages=123-136&pmid=7918097&doi=10.1016/0925-4773(94)90081-7&'s gross income?
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• How much does https://doi.org/10.1161/01.CIR.0000160870.93058.DD earn?
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• https://doi.org/10.1038/nature03080 income
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• https://doi.org/10.1038/nrm1911's total income per month
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• What's https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Placenta%20growth%20factor.%20Potentiation%20of%20vascular%20endothelial%20growth%20factor%20bioactivity,%20in%20vitro%20and%20in%20vivo,%20and%20high%20affinity%20binding%20to%20Flt-1%20but%20not%20to%20Flk-1/KDR&author=JE%20Park&author=HH%20Chen&author=J%20Winer&author=KA%20Houck&author=N%20Ferrara&volume=269&publication_year=1994&pages=25646-25654&pmid=7929268&'s gross income?
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• Monthly income for https://doi.org/10.2174/156652406776894527
• Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Curr%20Mol%20Med&title=From%20gut%20homeostasis%20to%20cancer&author=F%20Radtke&author=H%20Clevers&author=O%20Riccio&volume=6&publication_year=2006&pages=275-289&pmid=16712475&doi=10.2174/156652406776894527&
• How much income does https://doi.org/10.1006/excr.2000.5034 have?
• https://scholar.google.com/scholar_lookup?journal=Exp%20Cell%20Res&title=Isolation%20and%20characterization%20of%20the%20notch%20ligand%20delta4&author=PK%20Rao&author=M%20Dorsch&author=T%20Chickering&author=G%20Zheng&author=C%20Jiang&volume=260&publication_year=2000&pages=379-386&pmid=11035934&doi=10.1006/excr.2000.5034& income
• How much does https://doi.org/10.1046/j.1442-9071.2003.00602.x gross monthly?
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• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Mechanisms%20of%20angiogenesis&author=W%20Risau&volume=386&publication_year=1997&pages=671-674&pmid=9109485&doi=10.1038/386671a0& pull in?
• How much does https://doi.org/10.1038/ncb2096 bring in each month?
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• https://doi.org/10.1101/sqb.2005.70.052's financial summary
• What's the income generated by https://scholar.google.com/scholar_lookup?journal=Cold%20Spring%20Harb%20Symp%20Quant%20Biol&title=VEGF%20trap%20as%20a%20novel%20antiangiogenic%20treatment%20currently%20in%20clinical%20trials%20for%20cancer%20and%20eye%20diseases,%20and%20VelociGene-based%20discovery%20of%20the%20next%20generation%20of%20angiogenesis%20targets&author=JS%20Rudge&author=G%20Thurston&author=S%20Davis&author=N%20Papadopoulos&author=N%20Gale&volume=70&publication_year=2005&pages=411-418&pmid=16869778&doi=10.1101/sqb.2005.70.052& each month?
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• What's the income generated by https://doi.org/10.1096/fj.04-3172fje each month?
• See how much https://scholar.google.com/scholar_lookup?journal=FASEB%20J&title=Cell-autonomous%20notch%20signalling%20regulates%20endothelial%20cell%20branching%20and%20proliferation%20during%20vascular%20tubulogenesis&author=RC%20Sainson&author=J%20Aoto&author=MN%20Nakatsu&author=M%20Holderfield&author=E%20Conn&volume=19&publication_year=2005&pages=1027-1029&pmid=15774577&doi=10.1096/fj.04-3172fje& makes per month
• Revenue of https://doi.org/10.1182/blood-2006-12-063933
• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Blood&title=Inhibition%20of%20Dll4-mediated%20signalling%20induces%20proliferation%20of%20immature%20vessels%20and%20results%20in%20poor%20tissue%20perfusion&author=JS%20Scehnet&author=W%20Jiang&author=SR%20Kumar&author=V%20Krasnoperov&author=A%20Trindade&volume=109&publication_year=2007&pages=4753-4760&pmid=17311993&doi=10.1182/blood-2006-12-063933&?
• https://doi.org/10.1038/376062a0's total income per month
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Nature&title=Failure%20of%20blood-island%20formation%20and%20vasculogenesis%20in%20Flk-1-deficient%20mice&author=F%20Shalaby&author=J%20Rossant&author=TP%20Yamaguchi&author=M%20Gertsenstein&author=XF%20Wu&volume=376&publication_year=1995&pages=62-66&pmid=7596435&doi=10.1038/376062a0& generate?
• Financial intake of https://doi.org/10.1006/dbio.1996.0310
• How much money does https://scholar.google.com/scholar_lookup?journal=Dev%20Biol&title=Jagged2:%20A%20serrate-like%20gene%20expressed%20during%20rat%20embryogenesis&author=C%20Shawber&author=J%20Boulter&author=CE%20Lindsell&author=G%20Weinmaster&volume=180&publication_year=1996&pages=370-376&pmid=8948600&doi=10.1006/dbio.1996.0310& generate?
• https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=Dll4,%20a%20novel%20Notch%20ligand%20expressed%20in%20arterial%20endothelium&author=JR%20Shutter&author=S%20Scully&author=W%20Fan&author=WG%20Richards&author=J%20Kitajewski&volume=14&publication_year=2000&pages=1313-1318&pmid=10837024&'s revenue stream
• How much revenue does https://doi.org/10.1038/nature05577 generate?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Nature&title=Notch%20signalling%20limits%20angiogenic%20cell%20behaviour%20in%20developing%20zebrafish%20arteries&author=AF%20Siekmann&author=ND%20Lawson&volume=445&publication_year=2007&pages=781-784&pmid=17259972&doi=10.1038/nature05577&?
• How much does https://scholar.google.com/scholar_lookup?journal=Invest%20Ophthalmol%20Vis%20Sci&title=Oxygen-induced%20retinopathy%20in%20the%20mouse&author=LE%20Smith&author=E%20Wesolowski&author=A%20McLellan&author=SK%20Kostyk&author=R%20D%E2%80%99Amato&volume=35&publication_year=1994&pages=101-111&pmid=7507904& pull in monthly?
• Find out how much https://doi.org/10.1016/s0092-8674(00)81402-6 earns monthly
• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Cell&title=Neuropilin-1%20is%20expressed%20by%20endothelial%20and%20tumor%20cells%20as%20an%20isoform-specific%20receptor%20for%20vascular%20endothelial%20growth%20factor&author=S%20Soker&author=S%20Takashima&author=HQ%20Miao&author=G%20Neufeld&author=M%20Klagsbrun&volume=92&publication_year=1998&pages=735-745&pmid=9529250&doi=10.1016/s0092-8674(00)81402-6&?
• What's the monthly money flow for https://doi.org/10.1182/blood-2008-08-174508?
• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Blood&title=DLL1-mediated%20Notch%20activation%20regulates%20endothelial%20identity%20in%20mouse%20fetal%20arteries&author=I%20Sorensen&author=RH%20Adams&author=A%20Gossler&volume=113&publication_year=2009&pages=5680-5688&pmid=19144989&doi=10.1182/blood-2008-08-174508&?
• What is the monthly revenue of https://doi.org/10.1523/JNEUROSCI.15-07-04738.1995?
• Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=J%20Neurosci&title=Development%20of%20retinal%20vasculature%20is%20mediated%20by%20hypoxia-induced%20vascular%20endothelial%20growth%20factor%20(VEGF)%20expression%20by%20neuroglia&author=J%20Stone&author=A%20Itin&author=T%20Alon&author=J%20Pe%E2%80%99er&author=H%20Gnessin&volume=15&publication_year=1995&pages=4738-4747&pmid=7623107&doi=10.1523/JNEUROSCI.15-07-04738.1995&
• What's the financial gain of https://doi.org/10.1073/pnas.0611177104?
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• What is the earnings of https://doi.org/10.1042/CS20040370?
• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Clin%20Sci%20(Lond)&title=The%20vascular%20endothelial%20growth%20factor%20(VEGF)/VEGF%20receptor%20system%20and%20its%20role%20under%20physiological%20and%20pathological%20conditions&author=H%20Takahashi&author=M%20Shibuya&volume=109&publication_year=2005&pages=227-241&pmid=16104843&doi=10.1042/CS20040370&?
• Find out how much https://doi.org/10.1161/01.RES.0000254788.47304.6e earns monthly
• How much income does https://scholar.google.com/scholar_lookup?journal=Circ%20Res&title=Critical%20role%20of%20endothelial%20Notch1%20signalling%20in%20postnatal%20angiogenesis&author=K%20Takeshita&author=M%20Satoh&author=M%20Ii&author=M%20Silver&author=FP%20Limbourg&volume=100&publication_year=2007&pages=70-78&pmid=17158336&doi=10.1161/01.RES.0000254788.47304.6e& have?
• What's the financial intake of https://doi.org/10.1038/nature07083?
• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Nature&title=Blocking%20VEGFR-3%20suppresses%20angiogenic%20sprouting%20and%20vascular%20network%20formation&author=T%20Tammela&author=G%20Zarkada&author=E%20Wallgard&author=A%20Murtomaki&author=S%20Suchting&volume=454&publication_year=2008&pages=656-660&pmid=18594512&doi=10.1038/nature07083&?
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• How much income is https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=The%20human%20gene%20for%20vascular%20endothelial%20growth%20factor.%20Multiple%20protein%20forms%20are%20encoded%20through%20alternative%20exon%20splicing&author=E%20Tischer&author=R%20Mitchell&author=T%20Hartman&author=M%20Silva&author=D%20Gospodarowicz&volume=266&publication_year=1991&pages=11947-11954&pmid=1711045& earning monthly?
• Earnings of https://doi.org/10.1242/dev.122.7.2251
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Development&title=Notch4/int-3,%20a%20mammary%20proto-oncogene,%20is%20an%20endothelial%20cell-specific%20mammalian%20Notch%20gene&author=H%20Uyttendaele&author=G%20Marazzi&author=G%20Wu&author=Q%20Yan&author=D%20Sassoon&volume=122&publication_year=1996&pages=2251-2259&pmid=8681805&doi=10.1242/dev.122.7.2251&?
• How much revenue does https://doi.org/10.1073/pnas.091584598 produce monthly?
• How much money does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci&title=Vascular%20patterning%20defects%20associated%20with%20expression%20of%20activated%20Notch4%20in%20embryonic%20endothelium&author=H%20Uyttendaele&author=J%20Ho&author=J%20Rossant&author=J%20Kitajewski&volume=98&publication_year=2001&pages=5643-5648&pmid=11344305&doi=10.1073/pnas.091584598& make?
• How much does https://doi.org/10.1016/s0959-437x(98)80115-9 make?
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Genet%20Dev&title=Notch%20signalling:%20Direct%20or%20what?&author=G%20Weinmaster&volume=8&publication_year=1998&pages=436-442&pmid=9729720&doi=10.1016/s0959-437x(98)80115-9&?
• What is the earnings of https://doi.org/10.1242/dev.116.4.931?
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Development&title=Notch2:%20A%20second%20mammalian%20Notch%20gene&author=G%20Weinmaster&author=VJ%20Roberts&author=G%20Lemke&volume=116&publication_year=1992&pages=931-941&pmid=1295745&doi=10.1242/dev.116.4.931&
• How much cash flow does https://doi.org/10.1182/blood-2005-03-1000 have monthly?
• Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Blood&title=Up-regulation%20of%20the%20Notch%20ligand%20Delta-like%204%20inhibits%20VEGF-induced%20endothelial%20cell%20function&author=CK%20Williams&author=JL%20Li&author=M%20Murga&author=AL%20Harris&author=G%20Tosato&volume=107&publication_year=2006&pages=931-939&pmid=16219802&doi=10.1182/blood-2005-03-1000&
• See how much https://doi.org/10.1093/hmg/8.5.723 makes per month
• How much does https://scholar.google.com/scholar_lookup?journal=Hum%20Mol%20Genet&title=Embryonic%20lethality%20and%20vascular%20defects%20in%20mice%20lacking%20the%20Notch%20ligand%20Jagged1&author=Y%20Xue&author=X%20Gao&author=CE%20Lindsell&author=CR%20Norton&author=B%20Chang&volume=8&publication_year=1999&pages=723-730&pmid=10196361&doi=10.1093/hmg/8.5.723& gross monthly?
• How much cash flow does https://doi.org/10.1016/j.ccr.2005.06.004 have monthly?
• https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Crosstalk%20between%20tumor%20and%20endothelial%20cells%20promotes%20tumor%20angiogenesis%20by%20MAPK%20activation%20of%20Notch%20signalling&author=Q%20Zeng&author=S%20Li&author=DB%20Chepeha&author=TJ%20Giordano&author=J%20Li&volume=8&publication_year=2005&pages=13-23&pmid=16023595&doi=10.1016/j.ccr.2005.06.004& income
• What is the monthly revenue of https://github.com/ncbi?
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• How much does https://www.hhs.gov/ bring in each month?
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