
NCBI . NLM . NIH . GOV {
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Title[redir]:
FAS mediates non-canonical IL-1β and IL-18 maturation via caspase-8 in a Rip3-independent manner - PMC
Description:
Fas, a tumor necrosis factor family receptor, is activated by the membrane protein Fas ligand (FasL) expressed on various immune cells. Fas signaling triggers apoptosis and induces inflammatory cytokine production. Among the Fas induced cytokines, ...
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Keywords {🔍}
fas, ilβ, doi, caspase, activation, cells, pubmed, google, scholar, signaling, mfasl, inflammasome, pmc, rip, fig, bmdms, apoptosis, immunol, article, cytokines, nlrp, response, immune, macrophages, mice, pathway, priming, maturation, primed, bmdm, free, inflammatory, receptor, ligand, fasl, activity, pathways, asc, cell, nlm, family, cytokine, control, processing, expression, supplemental, nature, inflammasomes, downstream, release,
Topics {✒️}
beta-catenin/t-cell factor pathway cell-free membrane-bound fasl caspase-8/rip3 double-deficient mice fas-dependent th1-mediated apoptosis fas-mediated il-1β activation mfasl-mediated il-1β activation pro-inflammatory il-1β family fas-induced il-1β maturation abolished il-1β cleavage il-1β family members pmc beta search faslpr/lpr mice failed robustly activated wild-type isolated wild-type bmdm il-1β cytokine family stimulate il-1β release inhibit il-1β maturation induces pro-il-1β multi-protein signaling complexes il-1β cleavage downstream il-1β family cytokines fasl activates il-1β fas-induced il-1β cleave il-1β cytokines death-inducing signaling receptors il-1β elisa kit reactive oxygen species pro-il-1β production activate il-1β cytokines fas activates il-1β induce il-1β release pmc copyright notice fas ligand-induced apoptosis revealed il-1β maturation apoptosis-inducing membrane vesicles fas-dependent cell killing serum-free supernatants pattern recognition receptors activated il-1β results resident peritoneal macrophages endogenous danger signals peritoneal macrophages induced license information pmcid canonical il-1β german research foundation il-1β family canonical pathway involving fas-mediated killing anti-il-1β produce large amounts
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