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Title[redir]:
LKB1-AMPK axis revisited - PMC
Description:
The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy ...
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Keywords {🔍}
lkb, doi, cells, cancer, cell, ampk, stress, tumor, survival, lkbampk, pmc, energy, acc, pubmed, google, scholar, inactivation, pathway, article, metabolic, axis, activation, nature, nadph, free, nlm, role, mtor, suppressor, kinase, control, metabolism, growth, function, authors, glucose, fatty, ncbi, search, response, important, acid, polarity, homeostasis, types, epithelial, jeon, mechanisms, processes, levels,
Topics {✒️}
amp-activated protein kinase 5′-amp-activated protein kinase pmc beta search acetyl-coa carboxylase alpha acetyl-coa carboxylase beta p53 dominant-negative coexpression glucose-starved a549 cells oxidized glutathione/reduced glutathione lkb1-deficient lung cancer lkb1-deficient tumors bypass study lkb1-ampk-dependent survival context-specific tumor suppressor lkb1-ampk-acc1/2-nadph pathway starvation-induced cell death lkb1/stk11 inactivation leads lkb1-deficient cancer cells tca-oxidative phosphorylation cycles lkb1-mediated tumor suppression serine-threonine kinase publisher site pdf inhibited starvation-induced death tumor suppressor emerges shaw rj energy stress-induced apoptosis established tumor suppressor important ampk-independent functions anchorage-independent conditions references shackelford db increasing cellular amp rescue cell death license information pmcid intracellular metabolic processes lkb1 phosphorylates ampk enhanced cell survival adaptive napdh production acc inhibitor tofa lkb1-independent mechanisms a549 vector-transduced shrna-mediated knockdown negative feedback loop solid-tumor microenvironments prometastatic tumor subpopulation mol cell biol ectopically restoring lkb1 lkb1 null tumors glucose-deprived cells pmc disclaimer cancer cell lines improved cell survival vector-transduced cells
Questions {❓}
- Based on these results, a major question is raised: How do LKB1-deficient tumors bypass the normal requirement for the LKB1-AMPK axis in energy stress response?
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