
NCBI . NLM . NIH . GOV {
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Title[redir]:
Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism - PMC
Description:
Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are widely implicated in resistance of cancer cells to chemotherapy. The current study determined if simultaneous inhibition of GSH and Trx metabolism enhanced cell ...
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Keywords {🔍}
cells, cell, figure, bso, aur, bsoaur, activity, google, scholar, pubmed, fadu, cal, glutathione, doi, treatment, thioredoxin, gsh, hnscc, cancer, trx, versus, control, metabolism, killing, viability, reductase, treated, oxidative, results, tumor, clonogenic, stress, survival, free, pmc, significantly, increased, induced, compared, scc, error, cat, mice, dko, inhibition, experiments, article, resistance, egfr, assay,
Topics {✒️}
7 ng/ml triiodo-l-thyronine bso+aur-induced cell killing athymic-nu/nu nude mice bso+aur-induced cell death incubating bso+aur-treated lysates bso+aur-induced oxidative stress selenium-deficient rat liver viable bso+aur-treated cells bso+aur-treated tumors showed apotox-glo™ triplex assay pathogen-free barrier room form γ-glutamyl-cysteine bso+aur-induced cytotoxicity measured pmc beta search bax/bak double knockout bax/bak double-knockout bax−/−bak−/− double knock hydrogen peroxide-resistant fibroblasts h2o2-induced oxidative stress cat+bso+aur-treated fadu mk units/mg protein bso+aur induced parameters achieve maximal chemo-sensitization time-dependent pharmacodynamic models bso+aur-cell death bso+aur significantly sensitized bso+aur-induced cytotoxicity thioredoxin-thioredoxin reductase system nac completely reversed gold-based therapeutics agents cell killing induced h2o2-resistant cell lines necrotic cell death bso+aur induced gsh bax/bak-dependent process mouse hematopoietic cells inducing oxidative stress funding statement glutathione disulfide/glutathione couple bso+aur treated cells glutathione-dependent enzymes represent growth factor regulation xenograft-bearing mice additive cell killing drug induced cytotoxicity license information pmcid n-acetylcysteine bso-treated cal-27 cells bso+aur-treated fadu cancer cell killing
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- Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?
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