
NCBI . NLM . NIH . GOV {
}
Title[redir]:
GENETICS OF GENE EXPRESSION IN PRIMARY IMMUNE CELLS IDENTIFIES CELL-SPECIFIC MASTER REGULATORS AND ROLES OF HLA ALLELES - PMC
Description:
Trans-acting genetic variants play a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B-cells we identify novel, predominantly cell-specific, cis- and ...
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Keywords {🔍}
doi, expression, cell, google, scholar, pubmed, genes, pmc, association, article, eqtl, free, gene, specific, figure, bcells, supplementary, disease, monocytes, genet, alleles, hla, analysis, esnps, genomewide, primary, susceptibility, types, cellspecific, lyz, monocyte, type, nat, genetic, variants, study, highly, shared, pbcell, pmonocyte, directional, snps, cells, locus, region, mapping, data, snp, aoah, blood,
Topics {✒️}
peroxisome proliferator-activated receptor-gamma cell-specific trans-regulated networks include multi-locus trans-associations b-cell specific trans-eqtls undergoes nonsense-mediated decay european genome-phenome archive deoxyribonucleic acid-binding domain pmc beta search monocyte-specific master regulator genes showing cell-specific dr beta-chains depending multi-faceted transcriptional properties cis-eqtl involving rps26 master-regulatory regions specific genome-wide association studies cell-type specific manner3 multiple cell-specific trans b-cells x-axis pathogenic memory b-cells31 supertypic hla-drw53 specificity genome-wide association study real-time pcr quantification cell-specific cis-eqtl highly significant trans-eqtl genome-wide association data shared cis-eqtl/gwas snps performed quantitative rt-pcr implying trans-eqtls show monocyte specific cis-eqtl cd19+ primary b-cells b-cell data demonstrating monocyte-specific trans-association population-based linkage analyses b-cell data depicted significant cis-eqtl based cell type-dependent manner aids-nonprogression cohort emphasizes whilst cell-specific eqtls accession number e-mtab-945 esnps form cis-eqtl cell-specific eqtl analysis p53-mediated apoptosis30 primary cell populations monocyte specific cis-esnp separate cd19+ b-cells [google scholar] 67 b-cell trans expression class ii alleles population-scale sequencing cultured primary tissue
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