
NCBI . NLM . NIH . GOV {
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Title[redir]:
A tissue biopsy-based epigenetic multiplex PCR assay for prostate cancer detection - PMC
Description:
PSA-directed prostate cancer screening leads to a high rate of false positive identifications and an unnecessary biopsy burden. Epigenetic biomarkers have proven useful, exhibiting frequent and abundant inactivation of tumor suppressor genes through ...
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Keywords {🔍}
samples, doi, methylation, assay, cancer, prostate, multiplex, sample, dna, tissue, singleplex, actb, pubmed, google, scholar, copies, biopsy, copy, assays, rassf, epigenetic, apc, figure, micron, gstp, test, quantity, due, gene, genes, volume, age, relative, detection, number, results, pmc, effect, multiplexing, quality, biopsies, input, methylated, sufficient, van, screening, individual, numbers, amount, ffpe,
Topics {✒️}
pre-publication history typically formalin-fixed paraffin-embedded competing interests free prostate-specific antigen formalin-fixed paraffin-embedded real-time q-msp [google scholar] sing pmc beta search histopathologically cancer-negative tissues molecular-beacon-based approach license information pmcid supplementary materials included diagnostic tissue-based test characterizes dna-hypermethylated genes downstream q-msp analyses cancer-free individuals msp-based epigenetic assay abbreviations bph publisher site pdf insufficient input material cancer-free diagnosis [1-4] references djavan paired copy numbers relative contributions prostate-specific antigen prostate specific antigen adjusted r2-values q-msp results needle biopsy tissue false positive identifications routine psa screening conclusions screening authors read relative copy number lower tissue requirements generated output reaches 18-gauge needle produces written patient consent benign prostatic hyperplasia benign prostatic disease herman jg erroneous sample localization visualizing classifier performance complement psa screening discussion 1148–1149 biopsy tissue relative tissue minimization experiment paired samples presented q-msp analysis clin cancer res
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- Extended field prostate biopsies: too much of a good thing?
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