
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PMC
Description:
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an ...
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Keywords {🔍}
nqo, doi, estrogen, shikonin, cancer, cells, erα, breast, promoter, google, scholar, pubmed, mcf, activity, dna, transcription, pmc, nrf, luciferase, damage, inhibition, expression, tumor, treatment, gene, human, inhibits, mrna, fig, article, study, levels, estrogendependent, sirt, results, protein, free, signaling, enzymes, growth, ohdg, oxidative, activation, studies, induction, important, xenografts, receptor, dependent, binding,
Topics {✒️}
antiestrogen-liganded estrogen receptor-alpha shikonin inhibits estrogen–receptor-signaling subtype-matched anti-8-ohdg antibody estrogen–receptor-signaling pathway plays fitc-conjugated anti-igg antibody estrogen-dependent tumor growth quantitative real time-pcr quantitative real-time pcr gapdh house-keeping gene estrogen-induced dna damage estrogen-dependent gene promoters nrf2-dependent gene transcription conventional anti-estrogen agents reactive oxygen species estrogen-mediated gene expression small-cell lung cancer 5% charcoal/dextran-stripped fbs antagonist-occupied steroid receptors pmc beta search estrogen-receptor signaling pathway nf-e2-related factor 2 nrf2-dependent nqo1 transcription nqo1-deficient mcf-7 cells rt-pcr analysis shows real time-pcr erα ligand-binding domain time-dependent manner antioxidant response element estrogen-induced mammary dysfunctional keap1-nrf2 interaction estrogen signaling activates license information pmcid estrogen–receptor signaling estrogen receptor alpha ligand-dependent interaction full-length erα cdna wild-type mcf-7 xenografts class iii hdacs publisher site pdf shikonin inhibits erα deoxyribonucleic acid binding clin cancer res dependent detoxifying enzymes oxidative dna damage tumor cell implantation natl cancer inst concentration-dependent manner nqo1 gene promoter nqo1-dependent manner nqo1 dependent manner
Questions {❓}
- Is estradiol a genotoxic mutagenic carcinogen?
- Nrf2: friend or foe for chemoprevention?
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