
NCBI . NLM . NIH . GOV {
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Title[redir]:
Structure-Function Analysis of Human TYW2 Enzyme Required for the Biosynthesis of a Highly Modified Wybutosine (yW) Base in Phenylalanine-tRNA - PMC
Description:
Posttranscriptional modifications are critical for structure and function of tRNAs. Wybutosine (yW) and its derivatives are hyper-modified guanosines found at the position 37 of eukaryotic and archaeal tRNAPhe. TYW2 is an enzyme that catalyzes ...
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Keywords {🔍}
tyw, doi, htyw, yeast, residues, tumor, mammary, trnaphe, pubmed, google, scholar, protein, mouse, figure, base, sequences, human, expression, adomet, trna, pmc, analysis, tumors, alignment, cancer, gene, article, data, enzyme, proteins, pirsf, free, activity, normal, tissue, mutagenesis, strain, sequence, shown, amino, acids, domain, biosynthesis, modified, modification, rna, model, structures, structure, based,
Topics {✒️}
her2/neu oncogene [mmtv-her2/neu] bulky α-amino-α-carboxypropyl α-amino-α-carboxypropyl group single-linkage clustering mmtv/c-neu oncogene ods reverse-phase column real-time quantitative pcr mmtv-her2/neu [9] pmc beta search sc-ura/glucose media sc-ura/raffinose media aminoacyl-transfer rna populations tumour-specific phenylalanine trna structure-guided analysis identified make h-bond interactions hyper-modified guanosines found 32p-5′-end-labeled oligonucleotide yeast complementation test post-transcriptional base modifications gov/structure/cdtree/cdtree trna-yw synthesizing proteins residue forms h-bond yeast saccharomyces cerevisiae trna-wybutosine synthesizing enzyme oncogene [mmtv-pymt] mammary tumor tissue tumor mammary tissue tumor tissue contained [3h]-phenylalanine labeled normal x-linked dyskeratosis congenita tumor mouse trna mouse mammary tissues mouse mammary epithelium dna damage response structure-guided sequence alignment supplementary materials included tricyclic ring catalyzed normal mammary tissue trends biochem sci normal mouse tissue mammary tumor cells [14c]-phe trna panels show uv mammary tumor model mouse tumor model α-carboxy group [3h]-phe trna adomet-dependent methyltransferase scop license information pmcid α-amino group
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