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Title[redir]:
Penicillamine Increases Free Copper and Enhances Oxidative Stress in the Brain of Toxic Milk Mice - PMC
Description:
Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10–50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim ...
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Keywords {🔍}
copper, mice, atpa, brain, day, doi, free, increased, ctr, expression, cortex, treatment, administration, basal, ganglia, concentrations, serum, staining, pubmed, google, scholar, fold, cells, control, days, decreased, proteinbound, protein, oxidative, figure, layer, pyramidal, neurons, change, declined, level, group, significantly, study, mda, mouse, internal, stress, patients, mrna, controls, disease, sod, plexus, concentration,
Topics {✒️}
1371/annotation/e57c1988-71fd-4809-8d84-aff56e60b2c7 poly-l-lysine-coated slides peroxidase-conjugated anti-rabbit igg peroxidase-conjugated anti-goat igg oxidative-stress-related biomarkers assay oxidative-stress-related biomarker levels /research/gsc/resources/cndna peroxidase anti-chicken igg sun yat-sen university real-time quantitative pcr primescript rt-pcr kit pmc beta search synthesize single-strand cdna rabbit anti-ctr1 antibody gsh/gssg ratios revealed goat anti-atp7a antibody rabbit anti-golph2 antibody penicillamine-related neurologic syndrome anti-ctr1 primary antibodies protein-bound copper concentrations goat anti-nkcc1 antibody copper-induced oxidative damaged chicken anti-atp7a antibody gsh/gssg declined gradually publisher site pdf major water-soluble antioxidant conjugated donkey igg copper-mediated oxidative stress serum protein-bound copper protein-bound serum copper anti-chicken igg reduced glutathione/oxidized glutathione real time pcr goat anti-human license information pmcid methods ethic statement increased oxidative biomarkers colorimetric microplate assay β-actin mrna expression enhanced oxidative stress internal pyramidal layer excessive oxidative stress blood-brain barrier function menkes copper atpase gsh/gssg ratios gssg recycling assay clin chim acta goat anti-ctr1 enhances oxidative stress oxidative stress raised
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