
NCBI . NLM . NIH . GOV {
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Title[redir]:
The PSA−/lo prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration - PMC
Description:
Prostate cancer (PCa) is heterogeneous and contains both differentiated and undifferentiated tumor cells, but the relative functional contribution of these two cell populations remains unclear. Here we report distinct molecular, cellular, and ...
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Keywords {🔍}
cells, psalo, psa, figure, pca, tumors, lncap, lapc, gfp, doi, cell, tumor, cancer, mice, pubmed, google, scholar, purified, prostate, male, genes, androgen, shown, hpca, table, gfplo, expression, castrated, pmc, division, stem, distinct, analysis, derived, nodscid, article, numb, tumorigenic, type, levels, capacity, reporter, revealed, clones, larger, res, free, express, results, mrna,
Topics {✒️}
long-term tumor-propagating capacity genome-wide chip-seq analysis serum/androgen-free prebm medium male nod/scid-γ mice limited tumor-propagating capacity aldh−cd44−α2β1− lapc9 cells psa−/lo cell-derived tumors psa−/lo cell-originated tumors psa−/lo cell-derived spheres psap-gfp/pcmv-dsred lentivectors androgen/serum-free medium serum/androgen-free medium resist drug/stress treatments prostate-specific antigen expression fluorescence-activated cell sorting au/software/elda/index male nod/scid mice distinct tumor-propagating properties high-grade primary tumors possessed higher capacity psa−/lo cells contained psa−/lo hpca12 cells pmc beta search castrated nod/scid mice psa−/lo lapc9 cells psa−/lo cells express renewing tumor-initiating cells psa−/lo cells caused psa−/lo lncap cells psa−/lo tumors grew psa+/psa−/lo hpca18 psa−/lo pca cells bottom 2–6% gfp-negative/gfp-dim ruizeveld de winter psa−/lo tumor cells charcoal dextran-stripped serum female nod/scid mice lentiviral reporter system undifferentiated psa−/lo cells aldh+cd44+α2β1+ profile psa−/lo cancer cells psa−/lo hpca58 cells gfp−/lo lapc9 cells gfp−/lo lncap cells time-lapse video microscope psa−/lo cell population cell dose-dependent manner chromatin modifiers/epigenetic regulators aldh+cd44+α2β1+ cells aldh−cd44−α2β1− cells
Questions {❓}
- Are the preceding findings in PCa models (LNCaP, LAPC9, and LAPC4) applicable to patient tumors?
- These clinical observations raise a fundamental question: could PSA−/lo PCa cells be intrinsically distinct from PSA+ cells and thus play differential roles in tumor maintenance and progression to CRPC?
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