
NCBI . NLM . NIH . GOV {
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Title[redir]:
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells - PMC
Description:
Little is known about whether autophagic mechanisms are active in hematopoietic stem cells (HSCs) or how they are regulated. FIP200 (200-kDa FAK-family interacting protein) plays important roles in mammalian autophagy and other cellular functions, ...
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Keywords {π}
cells, fetal, doi, cko, mice, fip, hscs, liver, control, cell, figure, pubmed, google, scholar, embryos, blood, pmc, article, hematopoietic, deletion, autophagy, increased, free, stem, data, staining, ros, compared, hsc, observed, myeloid, peripheral, donor, results, number, nature, role, mitochondrial, livers, transplantation, increase, erythroid, recipients, consistent, lineage, protein, apoptosis, depletion, adult, mass,
Topics {βοΈ}
cd150+cd48βlinβmac-1+sca-1+ cells cd150+cd48βlinβmac1+sca1+ cells ulk1-atg13-fip200 complex involved tsc-mtor maintains quiescence atg5/atg7-independent alternative macroautophagy ulk1-atg13-fip200 complex required tsc-mtor signaling pathways retro-orbital venous sinus ulk-atg13-fip200 complex pmc beta search nutrient-dependent mtorc1 association blood web site ulk1-atg13-fip200 complex slam family receptors fip200-null purkinje cells increased cell-cycle progression page charge payment facsvantage se-dual laser fip200-null hematopoietic cells wild-type recipient mice supplementary materials included mx1-cre transgenic mice mx1-cre donor cells fetal liver-derived cd45 ulk-interacting protein fip200-null erythroid cells reactive oxygen species mx1-cre cells decreased tie2-cre transgenic mice critical cell-autonomous regulator fip200-null fetal hscs ros-mediated shortened lifespan focal adhesion kinase related kinase pyk2 rb regulates interactions increased hsc cycling haematopoietic stem cells diverse cellular activities ulk-fip200 complex biotin-conjugated sca1 discussion compared significantly increased numbers license information pmcid including myeloid lineage fetal liver sections hematopoietic stem cells key signaling node myeloid lineage progenitors hematopoietic cells leads significantly reduced reconstitution
Questions {β}
- Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?
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- Earnings of https://doi.org/10.4161/auto.5552
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