
NCBI . NLM . NIH . GOV {
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Title[redir]:
Humanin, a Cytoprotective Peptide, Is Expressed in Carotid Artherosclerotic Plaques in Humans - PMC
Description:
The mechanism of atherosclerotic plaque progression leading to instability, rupture, and ischemic manifestation involves oxidative stress and apoptosis. Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to ...
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Keywords {🔍}
doi, pubmed, google, scholar, plaque, cells, symptomatic, plaques, patients, apoptosis, humanin, carotid, atherosclerosis, pmc, atherosclerotic, asymptomatic, cell, article, expression, macrophages, free, expressed, disease, figure, mmp, greater, smooth, muscle, stroke, peptide, ischemic, protein, endothelial, group, stress, data, study, res, progression, compared, staining, apoptotic, inflammatory, role, alzheimers, human, mice, open, tab, factor,
Topics {✒️}
1371/annotation/1a60b239-181f-4d5f-9a37-3d3b04949954 goat anti-rabbit igg activated nuclear factor-kappab bcl-2/bax family proteins pmc beta search mitochondria-targeted antioxidant peptides hmg-coa reductase inhibitors rabbit anti-β-actin pro-apoptotic molecule igfbp-3 renin-angiotensin system blockers hn/β-actin standard symptomatic c-reactive protein expression apolipoprotein e-deficient mice dapi-impregnated mounting medium mouse anti-α-actinin anti-apoptotic factor humanin oxidized low-density lipoprotein β-actin densitometric signals tissue-specific macrophage subpopulations n-formylated humanin activates smooth muscle α-actinin mitochondria-specific antioxidative mechanisms late-stage necrotic atheroma oxidant-induced mitochondrial dysfunction jak2/stat3 pathway [46] late-stage atherosclerosis contributing double immunofluorescence labeling extracellular membrane receptor mitochondrial oxidative/apoptotic response jak2/stat3 axis neuronal cell death prevents cell-death neuronal cells exposed rescue factor humanin license information pmcid carl zeiss microimaging amyloid-β toxicity cerebral ischemic events formyl peptide receptor elevated plasma levels publisher site pdf curr drug targets specific cell types goat anti-mmp2 extracellular membrane surface mitochondria-targeted antioxidants foam cell phenotypes metabolo-protective factor smooth muscle cells ultrasound defining stenosis
Questions {❓}
- Diverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond?
- Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: Beneficial or detrimental?
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