
NCBI . NLM . NIH . GOV {
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Title[redir]:
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance - PMC
Description:
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has been uncertain. Using a state-of-the-art Taqman-based quantitative RT-PCR assay, we investigated the ...
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Keywords {๐}
cancer, cell, lines, doi, samples, expression, gene, genes, ovarian, clinical, pubmed, google, scholar, cells, types, models, nci, resistance, panel, vitro, tissue, analysis, pmc, mdr, tumor, primary, drug, article, data, fig, human, study, profiles, clustering, leukemia, national, profiling, free, line, carcinoma, breast, multidrug, cultured, response, type, melanoma, pathway, tumors, serous, values,
Topics {โ๏ธ}
immunodeficient beige/nude/scid mice sybr green-based qrt-pcr taqman-based qrt-pcr beige-nude-scid mice sybrgreen-based qrt-pcr atp-binding cassette transporters kb-cp20 cell line platinum-resistant cancers defined org/lookup/suppl/doi cell line-based platforms cisplatin-resistant cell lines pmc beta search atp-binding cassette gov/branches/btb/ivclsp anti-cancer drug development improved drug-discovery database ovcar-5 cell line open-source applications/databases platinum-sensitive clinical samples mcf-7 drug-resistant cells tumour suppressor p53 platinum-sensitive clinical specimens low attachment plate x-axis samples analyzed tukeyโkramer tests mdr-linked genes obtained gov/geo/query/acc human gene expression epithelial ovarian cancer supplementary materials included high positive values recapitulate ovarian carcinoma lysosomal drug sequestration supporting information online acute lymphoblastic leukemia anti-cancer treatment hg-u133a array p53 pathway activation publisher site pdf mdr gene profile candidate anticancer agents natl cancer inst acute myeloid leukemia drug-resistant subpopulation abc transporter genes national cancer institute' national cancer institute nat rev cancer gene expression profiles sensitive standard assay
Questions {โ}
- Are these subpopulations of cancer stem cells or other cells within clinical cancers that mimic the expression patterns in the cultured cells (either stem cell subpopulations or whole populations)?
- Do predictive signatures really predict response to cancer chemotherapy?
- How accurate are cancer cell lines?
- Models of ovarian cancerโare we there yet?
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Analytics and Tracking {๐}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {๐}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {๐ฆ}
- Ncbi