
NCBI . NLM . NIH . GOV {
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Title[redir]:
A critical role for TCF-1 in T-lineage specification and differentiation - PMC
Description:
The vertebrate thymus provides an inductive environment for T-cell development. Within the thymus, Notch signals are indispensable for imposing the T-cell fate on multipotential hematopoietic progenitors, but the downstream effectors that impart ...
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Keywords {π}
tcf, cells, doi, expression, notch, progenitors, tcell, development, fig, tlineage, pubmed, google, scholar, genes, pmc, mice, early, article, signals, thycd, gene, opdl, cell, tcfexpressing, free, lmpps, control, lineage, shown, transcription, stroma, specification, factor, upregulated, day, ectopic, pdf, binding, nihmssupplementpdf, immunol, expressed, gata, bclb, data, signaling, thymocytes, nlm, fate, thymic, factors,
Topics {βοΈ}
tcf-1-expressing linβsca1+kit+ paper footnotes references natural killer lineage progenitor development early lymphoid development hematopoietic stem cells adult lymphoid progenitors notch1f/fmxcre+rosayfp/+ lsk progenitors lymphoid-biased progenitors token=jpsdrykgkkggqhi&acc=gse26559 figure3a nk lineage23β25 t-cell lineage-specific genes tcf-1+/+ lineage-negative precursors cooperating pre-t-cell receptor tcf-1-expressing thy1+cd25+ lineage hsc tcf-1-directed t-lineage development tcf-1-expressing t-lineage cells tcf-1-expressing thy1+cd25+ cells early t-lineage development tcf-1+/+ lineage-negative cells normal t-cell development early t-cell development wnt1-cre-mediated deletion results early thymic progenitors b-cell fate early impart t-lineage specification wt t-depleted bm t-lineage specific genes early lymphopoiesis influences abrogate t-cell development9β11 Ξ³Ξ΄ t-cell lineages affect t-cell development15 observe t-cell leukemia t-cell lineage fate tcf-1-expressing thy1+cd25+ tcf-1β/β lsk progenitors control thy1+cd25+ lineage enhanced t-cell development lineage-negative cells yfp+ lsk progenitors t-lineage cells developing notch1f/fmxcre+rosayfp/+ mice30 key t-lineage genes generate thy1+cd25+ cells survival factor bcl-xl t-cell essential genes t-lineage cells developed downstream thymic populations sequence-specific hmg box
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