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Title[redir]:
Single-cell NF-κB dynamics reveal digital activation and analog information processing in cells - PMC
Description:
Cells operate in ever changing environments using extraordinary communication capabilities that emerge from the interactions of genetic circuitry. The mammalian immune response is a striking example of the coordination of different cell types.1 ...
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Keywords {🔍}
cells, tnfα, nfκb, doi, cell, expression, single, response, nuclear, fig, gene, time, model, google, scholar, doses, peak, genes, stimulation, pubmed, activation, concentration, supplementary, dynamics, signaling, measured, data, localization, active, science, pmc, intensity, ngml, early, microfluidic, level, experiments, dose, late, levels, nature, population, oscillations, article, figure, concentrations, range, culture, transcription, activity,
Topics {✒️}
regulate tnf-induced nf-kappab lipopolysaccharide-induced nf-kappab activation ikappab-nf-kappab signaling module core nf-κb network k-means clustered centroids reproducing nf-κb activity nf-κb nuclear localization unusual nf-kb activation persistent nf-κb oscillations nf-kappab regulatory module nf-κb localization dynamics link nf-κb dynamics nuclear nf-κb intensity retiga-srv ccd camera nuclear nf-κb intensities nf-kappab-dependent transcription negatively regulates nf-κb nf-kappab signaling pathway nf-kappab signaling control measured nf-κb activity signaling molecule tnf-α 01ng/ml tnf-α stimulation extra-cellular tnf-α nf-κb pathway activation cellular nf-kappab response measure nf-κb activity ikb kinase activity pmc beta search transcription factor nf-κb initial tnf-α concentration persistent tnf-α stimulation related dose-dependent parameter ikk subunits ikk-α decreasing tnf-α dose increasing tnf-α dose reproduces nf-κb dynamics initial tnf-α level high-throughput microfluidic techniques inducing tnf-α concentration control p65-fp expression tnf-α receptor levels nf-κb target genes low dose tnf-α tnf-α doses covering high-throughput quantitative measurements tnf-α concentration profile real-time fluorescent images tnf-α loaded media high tnf-α concentrations external tnf-α concentration
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