
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Adipose tissue remodeling and obesity - PMC
Description:
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent ...
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Keywords {π}
doi, google, scholar, pubmed, tissue, adipocytes, adipocyte, adipose, cell, pmc, article, free, remodeling, cells, expansion, obesity, angiogenesis, macrophages, fat, role, macrophage, insulin, obese, growth, hypoxia, inflammatory, clin, infiltration, endothelial, ecm, resistance, healthy, angiogenic, effects, expression, factor, key, studies, increased, death, lipid, inflammation, metabolic, diabetes, invest, jci, response, hypertrophy, vascular, ang,
Topics {βοΈ}
tumor necrosis factor-alpha oxygen-sensitive hif-1Ξ± subunit th1 cytokine ifn-Ξ³ nih grants r01-dk55758 robust pro-angiogenic response insulin-resistant skeletal muscle pmc beta search targeting ffa-mediated increases springer-verlag berlin heidelberg free fatty acids beta3-adrenergic receptor activation pmc copyright notice major energy-storing tissue cytotoxic t-cell infiltration obesity-induced insulin resistance secretion-trap expression cloning obesity-linked insulin resistance lipid-laden proinflammatory atmΟs fatty acid fluxes mt1-mmp impairs white pharmacological anti-obesity approaches obesity-related insulin resistance fatty acid flux concluding remarks publisher site pdf lipid-laden mature adipocytes differentiated 3t3-f442a adipocytes suggested anti-angiogenic properties insulin-resistant visceral depots macrophage-orchestrated inflammatory response classical hif-1Ξ± targets m1-stage macrophages prevail primary energy source tumor-derived angiogenesis tyrosine kinase receptors hfd-fed obese mice obesity-driven phenotypic switch tumor-suppressor protein diet-induced obese macrophage-related inflammatory genes diet-induced obesity systemic insulin resistance physiologically healthy response endothelial cell survival enhanced lipolytic rates major angiogenic factor vascular endothelial cells provide mechanical support inflammatory gene expression systemic insulin sensitivity
Questions {β}
- Hypertrophy versus hyperplasia?
- Is the macrophage involved in adipocyte turnover?
- Key questions to take into consideration are: what is the actual half-life of an adipocyte?
- So, where do ATMΦs fit into this equation of adipocyte turnover and AT expansion?
- These studies, however, raise further questions: given that obesity is associated with a higher adipocyte turnover due to an elevated rate of cell death (10), are there conditions in which a higher rate of preadipocyte recruitment, rather than loss of mature adipocytes through cell death, can occur?
- When and how do we transition from a physiologically healthy adaptive immune response to a pathological maladaptive state?
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- Discover the revenue of https://doi.org/10.1073/pnas.0308671100
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- How much does https://scholar.google.com/scholar_lookup?journal=Leukemia.&title=The%20history%20of%20angiogenesis%20inhibitors.&author=D%20Ribatti&volume=21&issue=8&publication_year=2007&pages=1606-1609&pmid=17637715&doi=10.1038/sj.leu.2404756& pull in monthly?
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- What's the profit of https://doi.org/10.1006/jsre.1996.4983?
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- Check the income stats for https://doi.org/10.1016/S0006-2952(00)00529-3
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Biochem%20Pharmacol.&title=Angiogenesis:%20regulators%20and%20clinical%20applications.&author=S%20Liekens&author=E%20De%20Clercq&author=J%20Neyts&volume=61&issue=3&publication_year=2001&pages=253-270&pmid=11172729&doi=10.1016/S0006-2952(00)00529-3&
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- How profitable is https://scholar.google.com/scholar_lookup?journal=PLoS%20One.&title=Blockade%20of%20VEGFR2%20and%20not%20VEGFR1%20can%20limit%20diet-induced%20fat%20tissue%20expansion:%20role%20of%20local%20versus%20bone%20marrow-derived%20endothelial%20cells.&author=J%20Tam&author=DG%20Duda&author=JY%20Perentes&author=RS%20Quadri&author=D%20Fukumura&volume=4&issue=3&publication_year=2009&pages=e4974&pmid=19333381&doi=10.1371/journal.pone.0004974&?
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- https://doi.org/10.1016/S0092-8674(00)81812-7's financial summary
- Profit of https://scholar.google.com/scholar_lookup?journal=Cell.&title=Isolation%20of%20angiopoietin-1,%20a%20ligand%20for%20the%20TIE2%20receptor,%20by%20secretion-trap%20expression%20cloning.&author=S%20Davis&volume=87&issue=7&publication_year=1996&pages=1161-1169&pmid=8980223&doi=10.1016/S0092-8674(00)81812-7&
- See how much https://doi.org/10.1126/science.277.5322.55 makes per month
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Science.&title=Angiopoietin-2,%20a%20natural%20antagonist%20for%20Tie2%20that%20disrupts%20in%20vivo%20angiogenesis.&author=PC%20Maisonpierre&volume=277&issue=5322&publication_year=1997&pages=55-60&pmid=9204896&doi=10.1126/science.277.5322.55&?
- Earnings of https://doi.org/10.1006/geno.1994.1536
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Genomics.&title=Assignment%20of%20the%20endothelial-specific%20protein%20receptor%20tyrosine%20kinase%20gene%20(TEK)%20to%20human%20chromosome%209p21.&author=DJ%20Dumont&author=L%20Anderson&author=ML%20Breitman&author=AM%20Duncan&volume=23&issue=2&publication_year=1994&pages=512-513&pmid=7835909&doi=10.1006/geno.1994.1536&?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Genes%20Dev.&title=Dominant-negative%20and%20targeted%20null%20mutations%20in%20the%20endothelial%20receptor%20tyrosine%20kinase,%20tek,%20reveal%20a%20critical%20role%20in%20vasculogenesis%20of%20the%20embryo.&author=DJ%20Dumont&volume=8&issue=16&publication_year=1994&pages=1897-1909&pmid=7958865&doi=10.1101/gad.8.16.1897&
- https://doi.org/10.1172/JCI118164 income
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