
NCBI . NLM . NIH . GOV {
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Title[redir]:
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation - PMC
Description:
Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with ...
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Keywords {🔍}
dotl, cells, doi, mice, cell, pubmed, google, scholar, blood, mll, bone, marrow, figure, dotlff, pmc, article, loss, mllaf, translocation, expression, data, hscs, free, tamoxifen, weeks, excision, methylation, oht, leukemia, deletion, required, eahlf, hoxa, injection, showed, progenitors, treatment, hematopoiesis, gene, transformation, meis, transplantation, hoxameis, histone, knockout, results, supplemental, days, lineage, examined,
Topics {✒️}
granulocyte-macrophage colony-stimulating factor mll-af9–transformed cells continued mll-enl-mediated cellular immortalization dot1l-deficient mll-af9 cells mll-af9–transformed cells failed polymerase chain reaction streptavidin-phycoerythrin-texas red exogenous wild-type dot1l wild-type dot1l construct full-length dot1l construct p-tefb kinase activation pmc beta search blood web site transfecting migr1-mll-af9 s-adenosylmethionine binding domain exogenous promoter-driven expression mll-af9–transformed cells page charge payment retrovirally transduced hrx-enl examining cell-autonomous effects e2a-hlf cells continued mll-af9 cells led mll-af9 cells treated human mll-af4 leukemias mll translocation-mediated leukemias mll fusion protein short-lived myeloid cells methods mouse strains wild-type microenvironment mll translocation-mediated leukemogenesis supplementary materials included e2a-hlf transformed cells misguided transcriptional elongation transcriptional elongation proteins wild-type dot1l recipient bone marrow full-length dot1l cdx2/cdx4 upregulation knockout mouse project cells minimally remained bone marrow hypocellularity wild-type competitors mll translocation protein mouse breeding colony wild-type cd45 hoxa9/meis1-transformed cells high-copy disruptors selected mll-af9 mll-af9 oncogene competitive transplantation experiments
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- What's the financial gain of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- How much revenue does https://www.nlm.nih.gov/web_policies.html produce monthly?
- https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office's total income per month
- What's https://www.hhs.gov/vulnerability-disclosure-policy/index.html's gross income?
- How much cash flow does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal have monthly?
- What's the profit of https://www.nlm.nih.gov/accessibility.html?
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- What are the earnings of https://www.nlm.nih.gov/?
- Revenue of https://www.nih.gov/
- What's the financial intake of https://www.hhs.gov/?
- What's the profit of https://www.usa.gov/?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Knockout.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi