
NCBI . NLM . NIH . GOV {
}
Title[redir]:
27-Hydroxycholesterol: the First Identified Endogenous SERM - PMC
Description:
The cholesterol metabolite 27-hydroxycholesterol (27HC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27HC also uniquely binds to and modifies estrogen ...
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Keywords {π}
doi, pubmed, google, scholar, estrogen, mice, bone, cypb, cholesterol, serm, erΞ±, pmc, receptor, cells, cardiovascular, breast, cancer, article, actions, oxysterol, free, impact, endogenous, levels, enos, women, hydroxycholesterol, effects, studies, cell, important, disease, vascular, postmenopausal, atherosclerosis, human, oxysterols, endothelial, bile, erΞ², function, selective, lipid, hormone, res, nlm, synthesis, cypa, mineralization, gene,
Topics {βοΈ}
estrogen receptor-alpha mediates sterol 27-hydroxylase immuno-reactivity gal4 dna-binding domain estrogen-related cardiovascular protection oxysterol 7Ξ±-hydroxylase encoded oxysterol 7alpha-hydroxylase gene cells entering s-phase pmc beta search e2-related cardiovascular protection high cholesterol/high fat er-mediated processes involved blunts e2-induced reendothelialization ere-medited transcriptional transactivation estrogen receptor-alpha akt kinase-dependent activation disease stage-dependent accumulation 27hc inhibited 17Ξ²-estradiol cell-type selective ovariectomized female mice future directions trends endocrinol metab erΞ±-expressing hela cells resulting 7Ξ±-hydroxylated forms estrogen/progestin replacement study ovariectomy-induced bone loss e2-induced endothelial repair bone mineral density sterol-sensitive genes cardiovascular protection afforded stimulates cell growth e2 promotes reendothelialization activates kinase signaling mammalian 2-hybrid assays protein oxidation products modifies estrogen receptor estrogen receptor pharmacology estrogen receptor-beta estrogen receptor beta license information pmcid nih grant hl087564 publisher site pdf breast cancer growth primary endothelial cells promote cell growth endogenous ligand capable ligand-induced conformational clin endocrinol metab cholesterol 7Ξ±-hydroxylase[11] display inhibitory effects stimulate pi3 kinase
Questions {β}
- Are side-chain oxidized oxysterols regulators also in vivo?
- Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?
- What do we know about the mechanisms of aromatase inhibitor resistance?
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- How much does https://github.com/ncbi pull in?
- https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323's revenue stream
- How much income does https://www.nlm.nih.gov/web_policies.html have?
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Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {π}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {π¦}
- Ncbi