
NCBI . NLM . NIH . GOV {
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Title[redir]:
Treatment with an Interleukin 1 beta antibody improves glycemic control in diet induced obesity - PMC
Description:
The proinflammatory cytokine Interleukin 1 beta (IL-1β) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. In this study we describe ...
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Keywords {🔍}
doi, antibody, ilβ, insulin, treatment, pubmed, google, scholar, mice, control, levels, obesity, fat, diet, interleukin, obese, glucose, treated, diabetes, resistance, high, beta, ilra, receptor, study, group, animals, pmc, significant, human, pancreatic, effects, weeks, islet, relative, significantly, groups, reduced, serum, increased, islets, mouse, effect, fig, body, weight, low, article, cell, glycated,
Topics {✒️}
combined anti-tnf-alpha/anti-cd4 therapy tumor necrosis factor-alpha extracellular signal-regulated kinase anti-mouse il-1β antibody t-cell-dependent antibody production anti-idiotypic antibody preparation interleukin-1beta-induced insulin resistance anti-il-1β antibody glucose-infusion rat model regulated acute-phase proteins pmc beta search leica dm-il microscope il-1β antibody leads anti-il-1β treatment il-1 mediated cytotoxicity cytokine-induced sickness behavior il-1β antibody represents il-1beta-deficient mice collagen-induced arthritis il-1β antibody treatment slow/prevent disease progression employed recombinant il-1ra obesity-insulin resistance-t2d spectrum inflammation-sensitive plasma proteins proinflammatory cytokine il-1β cytokine-induced insulin resistance wako-l-type tg il-1 mediated signaling nefa wako nefa-hr antibody treated animals control treated group obesity develops il-1β beta-cell mass reach statistical significance anti-inflammatory cytokine il-1β concentrations observed elevated circulating il-1ra chronic inflammatory/autoimmune disease anti-inflammatory proteins beta cell survival serum il-1ra levels major risk factor pancreatic beta cells insulin-dependent diabetes mellitus insulin-dependent diabetes mellitus control antibody group control treated animals therapeutic strategy protects interleukin-1 receptor antagonist interleukin-1-receptor antagonist
Questions {❓}
- C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?
- IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?
- Is type 2 diabetes a chronic inflammatory/autoimmune disease?
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