
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene - PMC
Description:
Genetic rearrangements of the anaplastic lymphoma kinase (ALK) kinase occur in 3% to 13% of non–small cell lung cancer patients and rarely coexist with KRAS or EGFR mutations. To evaluate potential treatment strategies for lung cancers driven by an ...
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Keywords {🔍}
doi, emlalk, lung, cancer, hsp, google, scholar, tumor, fig, pubmed, alk, treatment, mice, kinase, cells, inhibition, supplementary, inhibitor, expression, pmc, dmag, cell, model, treated, gene, article, tae, tumors, egfr, cancers, murine, weeks, mouse, free, fusion, inhibitors, effective, signaling, proteins, clinical, lymphoma, regression, activity, therapeutic, protein, hours, previously, analysis, western, res,
Topics {✒️}
cross-species gene-expression analysis gel-free lc-ms/ms method 18f-fdg-pet-ct scans revealed eml4-alk–driven lung cancer eml4-alk–specific expression signature doxycycline-dependent lung-specific induction eml4-alk–driven h3122 xenografts eml4-alk tumor-bearing mice rank-ordered gene list pathogen-free animal facility mutant egfr-expressing tumors structure-based virtual screening alk-rearranged lung cancer alk-rearranged lung cancers bcr-abl gene mutation tumors harboring eml4-alk combined pi3k/mtor/mek inhibition small-cell lung cancer eml4-alk lung cancer kaplan–meier survival analysis expressed eml4-alk driven eml4-alk gene sets egfr-driven tumor samples eml4-alk fusion gene tfg-alk fusion transcripts eml4-alk–expressing compared eml4-alk fusion oncoprotein eml4-alk fusion transcripts nucleophosmin-anaplastic lymphoma kinase h3122-jp1536ha–expressing cells eml4-alk fusion protein v600e b-raf requires potential eml4-alk effector pmc beta search potent anti-inflammatory agent primary lung cancers eml4-alk mouse model eml4-alk expression led hsp90-client tyrosine kinase providing npm-alk plasmid tumor-bearing mice untreated h3122-eml4-alk-jp1536ha water-soluble geldanamycin 17-dmag lung cancers driven human eml4-alk nsclc normal lung structure advanced lung cancer flag-tagged protein lc-ms/ms lysates entire kinase domain
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- How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=Selective%20chemical%20probe%20inhibitor%20of%20Stat3,%20identified%20through%20structure-based%20virtual%20screening,%20induces%20antitumor%20activity&author=K%20Siddiquee&author=S%20Zhang&author=WC%20Guida&author=MA%20Blaskovich&author=B%20Greedy&volume=104&publication_year=2007&pages=7391-6&pmid=17463090&doi=10.1073/pnas.0609757104& make?
- What's https://doi.org/10.1073/pnas.0905056106's gross income?
- How much money does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=Differential%20induction%20of%20apoptosis%20in%20HER2%20and%20EGFR%20addicted%20cancers%20following%20PI3K%20inhibition&author=AC%20Faber&author=D%20Li&author=Y%20Song&author=MC%20Liang&author=BY%20Yeap&volume=106&publication_year=2009&pages=19503-8&pmid=19850869&doi=10.1073/pnas.0905056106& generate?
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- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Pharmacol&title=The%20JAK-3%20inhibitor%20CP-690550%20is%20a%20potent%20anti-inflammatory%20agent%20in%20a%20murine%20model%20of%20pulmonary%20eosinophilia&author=E%20Kudlacz&author=M%20Conklyn&author=C%20Andresen&author=C%20Whitney-Pickett&author=P%20Changelian&volume=582&publication_year=2008&pages=154-61&pmid=18242596&doi=10.1016/j.ejphar.2007.12.024& each month?
- https://doi.org/10.1016/S0065-230X(06)95009-X income
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- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=The%20impact%20of%20human%20EGFR%20kinase%20domain%20mutations%20on%20lung%20tumorigenesis%20and%20in%20vivo%20sensitivity%20to%20EGFR-targeted%20therapies&author=H%20Ji&author=D%20Li&author=L%20Chen&author=T%20Shimamura&author=S%20Kobayashi&volume=9&publication_year=2006&pages=485-95&pmid=16730237&doi=10.1016/j.ccr.2006.04.022&?
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- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Ubiquitination%20and%20proteasomal%20degradation%20of%20nucleophosmin-anaplastic%20lymphoma%20kinase%20induced%20by%2017-allylamino-demethoxygeldanamycin:%20role%20of%20the%20co-chaperone%20carboxyl%20heat%20shock%20protein%2070-interacting%20protein&author=P%20Bonvini&author=H%20Dalla%20Rosa&author=N%20Vignes&author=A%20Rosolen&volume=64&publication_year=2004&pages=3256-64&pmid=15126367&doi=10.1158/0008-5472.can-03-3531&?
- How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Nucleophosmin-anaplastic%20lymphoma%20kinase%20(NPM-ALK),%20a%20novel%20Hsp90-client%20tyrosine%20kinase:%20down-regulation%20of%20NPM-ALK%20expression%20and%20tyrosine%20phosphorylation%20in%20ALK(+)%20CD30(+)%20lymphoma%20cells%20by%20the%20Hsp90%20antagonist%2017-allylamino,17-demethoxygeldanamycin&author=P%20Bonvini&author=T%20Gastaldi&author=B%20Falini&author=A%20Rosolen&volume=62&publication_year=2002&pages=1559-66&pmid=11888936& generate monthly?
- How much profit does https://doi.org/10.1016/j.exphem.2006.07.002 make?
- How profitable is https://scholar.google.com/scholar_lookup?journal=Exp%20Hematol&title=The%20HSP90%20inhibitor%2017-AAG%20synergizes%20with%20doxorubicin%20and%20U0126%20in%20anaplastic%20large%20cell%20lymphoma%20irrespective%20of%20ALK%20expression&author=GV%20Georgakis&author=Y%20Li&author=GZ%20Rassidakis&author=LJ%20Medeiros&author=A%20Younes&volume=34&publication_year=2006&pages=1670-9&pmid=17157164&doi=10.1016/j.exphem.2006.07.002&?
- See how much https://doi.org/10.1371/journal.pone.0000810 makes per month
- How much does https://scholar.google.com/scholar_lookup?journal=PloS%20One&title=Development%20of%20new%20mouse%20lung%20tumor%20models%20expressing%20EGFR%20T790M%20mutants%20associated%20with%20clinical%20resistance%20to%20kinase%20inhibitors&author=L%20Regales&author=MN%20Balak&author=Y%20Gong&author=K%20Politi&author=A%20Sawai&volume=2&publication_year=2007&pages=e810&pmid=17726540&doi=10.1371/journal.pone.0000810& make?
- https://scholar.google.com/scholar_lookup?journal=J%20Clinl%20Oncol&title=Association%20between%20anaplastic%20lymphoma%20kinase%20rearrangements%20(rALK)%20and%20the%20clinical%20activity%20of%20IPI-504%20(retaspimycin%20hydrochloride),%20a%20novel%20Hsp90%20inhibitor,%20in%20patients%20with%20non-small%20cell%20lung%20cancer%20(NSCLC)%20%5BAbstract%5D&author=LV%20Sequist&author=RB%20Natale&author=NN%20Senzer&author=R%20Martins&author=R%20Lilenbaum&volume=28&issue=Suppl&publication_year=2010&pages=7517&'s financial summary
- Revenue of https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Oncol&title=A%20phase%20I%20dose%20escalation%20study%20of%20AUY922,%20a%20novel%20HSP90%20inhibitor,%20in%20patients%20with%20advanced%20solid%20malignancies%20%5BAbstract%5D&author=C%20Sessa&author=SK%20Sharma&author=CD%20Britten&author=NJ%20Vogelzang&author=KN%20Bhalla&volume=27&issue=Suppl&publication_year=2009&pages=3532&
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- How much profit does https://www.nlm.nih.gov/web_policies.html make?
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