NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3019762/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3019762/. The analysis below is for the second page.
Title[redir]:
Bmi-1 is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation - PMC
Description:
The Polycomb group transcriptional repressor Bmi-1 is often up-regulated in prostate cancer, but its functional roles in prostate stem cell maintenance and prostate cancer are unclear. Loss- and gain-of-function analysis in a prostate sphere assay ...
Title[redir]:
Bmi-1 is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation - PMC
Description:
The Polycomb group transcriptional repressor Bmi-1 is often up-regulated in prostate cancer, but its functional roles in prostate stem cell maintenance and prostate cancer are unclear. Loss- and gain-of-function analysis in a prostate sphere assay ...
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- Science
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๐ Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {๐}
bmi, cells, prostate, doi, cell, stem, infected, shrna, selfrenewal, cancer, spheres, figure, google, scholar, pubmed, sphere, signaling, pmc, scrambled, expression, activity, article, grafts, free, loss, ฮฒcatenin, normal, tubules, data, mice, primary, proliferation, fgf, forming, wnt, lawson, adult, population, show, levels, sections, representative, images, rfp, analysis, regeneration, mammary, mouse, xin, dissociated,
Topics {โ๏ธ}
references asselin-labat ml pmc beta search 1mg/ml dispase solution polycomb-group oncogenes ezh2 semi-solid sphere assay bmi-1res lentivector constructs brdu pulse-chase experiments pulse-chase marking experiments pten-null prostate cells cb17scid/scid mouse strains target genes c-myc cre infected catnb+/lox involve proto-oncogenic pathways mu-myc transgenic mice peroxidase-conjugated secondary antibodies beta-catenin-tcf signaling basal/stem cell population proximal-distal ductal axis cre/scrambled shrna grafts heightened beta-catenin signaling ptenloxp/loxp cells infected bmi-1res completely rescued heightened ฮฒ-catenin signaling ptenloxp/loxp prostate cells p63-null stem cells cre/bmi-1 shrna lentivirus ฮฒ-catenin activity leads activate ฮฒ-catenin signaling shown label-retaining cells bmi-1-green fluorescent protein-knock ฮฒ-catenin target genes polycomb group genes morphogenetic shh-gli signaling polycomb group proteins supplementary materials included androgen ablation therapy wechsler-reya pten-null prostate prostatic tubule regeneration prostate cancer foundation adult mouse prostate dna cell biol maintain organ homeostasis cell stem cell pten deletion leads exogenous bmi-1 show adult prostate cells trop2lo basal-subpopulations cre/bmi-1 shrna van leenders
Questions {โ}
- Is the Achillesโ heel for prostate cancer therapy a gain of function in androgen receptor signaling?
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- How much does https://scholar.google.com/scholar_lookup?journal=Developmental%20biology&title=Clonal%20and%20population%20analyses%20demonstrate%20that%20an%20EGF-responsive%20mammalian%20embryonic%20CNS%20precursor%20is%20a%20stem%20cell&author=BA%20Reynolds&author=S%20Weiss&volume=175&publication_year=1996&pages=1-13&pmid=8608856&doi=10.1006/dbio.1996.0090& rake in every month?
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