NCBI . NLM . NIH . GOV {
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Title[redir]:
Top-down morphogenesis of colorectal tumors - PMC
Description:
One of the fundamental tenets of oncology is that tumors arise from stem cells. In the colon, stem cells are thought to reside at the base of crypts. In the early stages of tumorigenesis, however, dysplastic cells are routinely found at the luminal ...
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Keywords {🔍}
cells, crypts, normal, doi, dysplastic, adenomas, epithelium, apc, google, scholar, pubmed, adenomatous, fig, epithelial, small, loh, underlying, crypt, base, superficial, observed, top, dna, pcr, mutations, stem, cell, cancer, staining, βcatenin, lesions, stained, allelic, shown, pattern, search, pmc, nlm, colorectal, bases, gene, mucosae, bottom, normalappearing, microdissected, alleles, topdown, kinzler, vogelstein, morphologically,
Topics {✒️}
[α-33p]-labeled dideoxynucleotide triphosphates β-catenin/tcf4 transcription complexes paraffin-embedded tissue blocks stimulating β-catenin degradation micrometer-thick sections obtained single-stranded dna complementary anti-β-catenin antibody normal-appearing epithelial cells pmc beta search single-nucleotide polymorphic markers β-catenin staining patterns publisher site pdf single-nucleotide polymorphism johns hopkins hospital adenomatous polyposis coli bio-tek solutions wild-type apc sequence familial adenomatous polyposis sporadic adenomatous polyps β-catenin initiate β-catenin expression johns hopkins university license information pmcid high-grade dysplasia natl cancer inst routine epithelial turnover absorptive epithelial cells normal epithelial cells nucleotide substitutions resulting β-catenin antibody digital snp analysis mutation cluster region nucleotide sequence analysis microdissected fractions consisted β-catenin present normal epithelial layer lesions exhibiting loh normal colonic mucosae adenomatous polyps proceeds normal-appearing epithelium relevant cell populations surrounding cell layers tian-li wang shmuel ben-sasson ‡ avidin-biotin peroxidase reaction products detected galaxy fluostar fluorometer bmg lab technologies inhibiting transcriptional activation curves depicting probabilities
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