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Title[redir]:
GCTA: A Tool for Genome-wide Complex Trait Analysis - PMC
Description:
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex trait analysis (GCTA), ...
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Keywords {🔍}
snps, variance, genetic, doi, gcta, google, scholar, estimate, effects, data, pubmed, analysis, chromosome, heritability, explained, model, pmc, genomewide, individuals, article, matrix, complex, association, snp, estimation, grm, free, based, variants, genet, trait, allele, causal, method, function, vector, set, genetics, human, traits, gwas, estimating, variation, dosage, large, relationship, pairs, missing, compensation, number,
Topics {✒️}
genome-wide significance level genome-wide association studies genome-wide association analysis genome-wide marker data markov chain-based haplotyper genome-wide association loci sequence-level population simulations high-order genetic variation pmc beta search hardy-weinberg equilibrium test pmc copyright notice x-linked phenotypic covariance x-linked genetic variance web resources gene-gene interaction effects genotype-environment interaction effects /csg/yli/mach plink additive-environment interaction effects publisher site pdf main text single-snp association analysis complex trait variation pedigree-based estimator captures male-female genetic correlation population-based linkage analyses case-control study full dosage compensation gene-environment interaction gene-gene interaction genome-wide snps [google scholar] 11 [google scholar] 14 [google scholar] 17 [google scholar] 22 [google scholar] 23 [google scholar] 29 [google scholar] 33 snp-derived grm matrix genetic analysis packages input data format license information pmcid dna structural variation spurious allelic association unobserved liability scales human complex diseases additive genetic variation united states government remains largely unexplained major operating systems medical research council
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