
NCBI . NLM . NIH . GOV {
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Title[redir]:
C/EBPβ Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary Gland - PMC
Description:
The bZIP transcription factor C/EBPβ is important for mammary gland development and its expression is deregulated in human breast cancer. To determine whether C/EBPβ regulates mammary stem cells (MaSCs), we employed two different knockout ...
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Keywords {🔍}
cebpβ, cells, doi, cell, mammary, pubmed, google, scholar, glands, wildtype, luminal, stem, mecs, mice, gland, pmc, decreased, expression, article, progenitor, development, deletion, free, analysis, compared, differentiation, cancer, transplantation, mascs, outgrowth, results, cfp, fat, fig, subpopulation, data, fate, germline, ability, cebpβnull, alveolar, ductal, shown, transplanted, outgrowths, breast, mammosphere, masc, isolated, lineage,
Topics {✒️}
suppl methods nihms195102-supplement-suppl_methods ccaat/enhancer binding protein-beta β-actin-cyan fluorescent protein ccaat/enhancer binding protein rbp-j-deleted glands contained rbp-j-null mammary glands dominant-negative transcription factor real-time pcr validation ccaat/enhancer binding proteins wnt/β-catenin signaling pmc beta search single-hit poisson model single-hit poisson distribution single-hit poisson assumption ras-transformed mouse fibrobasts small proline-rich protein stem/progenitor cell populations normal stem/progenitor cells long-term repopulating activity ultra-low attachment plates lin−cd24+cd29hi cells liver-enriched inhibitory protein evaluate stem/progenitor cells lin−cd24+cd29hi subpopulation regulate stem/progenitor cell promyelocytic leukemia protein differentiation remain ill-defined scid/beige recipient mice luminal cell-fate commitment generalized linear model adenovirus-cre-mediated recombination female scid/beige mice serum-free media {micro}-mir-155 transgenic mice /ebpβ-null epithelium failed lin− cd24hicd29lo subpopulationa mediate oncogene-induced senescence secondary mammospheres formed human breast cancer bzip transcription factor supplementary materials included specifies masc fate lin−cd24hicd29lo luminal subpopulation cre-mediated gene deletion breast cancer subtypes 1mg/ml x-gal lin−cd24+cd29hi /ebp βfl/fl mice adult mammary gland masc repopulation activity
Questions {❓}
- Minireview: hormones and mammary cell fate--what will I become when I grow up?
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