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Keywords {🔍}

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Topics {✒️}

pten-deficient cd150+cd48−cd41−lin−c-kit+sca-1+ cells donor cd150+cd48−cd41−lin−c-kit+sca-1+ hscs cd150+cd48−cd41−lin−c-kit+sca-1+ donor hscs stained cd150+cd48−cd41−lin−c-kit+sca-1+ hscs sorted cd150+cd48−cd41−lin−c-kit+sca-1+ hscs cd150−cd48−cd41−lin−c-kit+sca-1+ donor mpps 10 cd150+cd48−cd41−lin−c-kit+sca-1+ cells cd150+cd48−cd41−lin−c-kit+sca-1+ hscs cd150+cd48−cd41−lin−sca-1+c-kit+ hscs cd150−cd48−cd41−lin−c-kit+sca-1+ mpps c-kit+flk-2−lin−sca-1+cd48− cells c-kit+flk-2−lin−sca-1+cd48− hscs c-kit+lin−sca-1+ cells pten-deficient lin−c-kit+ cells pten-deficient lineage−c-kit+ cells biotin-conjugated anti-c-kit biotin-conjugated c-kit staining pe/cy5-conjugated anti-cd150 biotin-conjugated c-kit pe/cy5-conjugated anti-flk-2 selecting c-kit+ cells long-term multilineage reconstitution c-kit+ enriched cells trp53−/−p16ink4a−/−p19arf−/− multipotent progenitors ptenfl/flmx-1-cre+p19arf−/− hscs died ptenfl/flmx-1-cre+p16ink4a/p19arf−/− cells pe-conjugated anti-cd41 long-term multilineage reconstituted pe-conjugated anti-cd48 pe-conjugated anti-cd150 long-term haematopoietic reconstitution fitc-conjugated anti-cd41 apc-conjugated anti-sca-1 fitc-conjugated anti-cd48 n-acetyl-l-cysteine ptenfl/flmx-1-cre+p19arf−/− cells ptenfl/flmx-1-cre+p53−/− cells 10 ptenfl/flmx-1-cre+p16ink4a−/− hscs ptenfl/flmx-1-cre+p16ink4a−/− hscs 10 ptenfl/flmx-1-cre+p53−/− hscs antioxidant n-acetyl-cysteine pten+/flmx-1-cre+ control hscs paramagnetic anti-biotin microbeads pten+/flmx-1-cre+ control mice ptenfl/flmx-1-cre+ cells pmc beta search young adult wild-type ptenfl/flmx-1-cre+ hscs 10 ptenfl/flmx-1-cre+ hscs pten+/flmx-1-cre+ controls

Questions {❓}

• How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

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