
NCBI . NLM . NIH . GOV {
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Title[redir]:
CD4+ T-cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation - PMC
Description:
Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the induction and restraint of tumorigenesis, but their role in oncogene inactivation mediated tumor regression is unclear. Here, we show that an intact ...
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Keywords {🔍}
doi, tumor, myc, inactivation, immune, pubmed, google, scholar, hosts, tumors, rag, regression, figure, mice, versus, cancer, system, cells, tcells, oncogene, tsp, cell, sustained, host, angiogenesis, senescence, expression, pmc, cellular, bcrabl, article, free, required, panel, nature, induce, fold, staining, role, cytokines, intact, apoptosis, shown, addiction, effectors, immunodeficient, data, felsher, shut, transgenic,
Topics {✒️}
ikk/nf-kappab activation pathway integrin-dependent t-lymphocyte adhesion tet-o-bcr-abl mice long-lasting anti-tumor immunity tnf-related apoptosis-inducing ligand inhaled isoflorane/oxygen delivered pro-b-cell leukemia pmc beta search bcr-abl-induced b bcr-abl induced b increased sa-β-gal staining inducing t-cell tolerance interleukin-dependent inflammatory network cd4+ t-cells occurs tumor-free survival tumor free survival cd4+ t-cells impairs luciferase+cd4+ t-cells luciferase+ cd4+ t-cells cd4+ t-cells emerged bcr-abl inactivation appeared rag2−/−cd4+ versus rag2−/−cd8+ oncogene-induced senescence relayed cd8+ t-cells isolated versus immunodeficient bcr-abl potent anti-angiogenic protein cd4+ t-cell effectors bcr-abl oncogene resulted translocations involving c-myc cd4+ t-cell function increased sa-β-gal specifically cd4+ t-cells cd4+ t-cells home lymphoma research foundation tumor-promoting m2 macrophages tumor-infiltrating immune cells cd8+ t-cell deficiency references acosta jc host-immune dependent mechanisms cd8+ t-cell reconstitution van der bruggen inderberg-suso em ifn-gamma-dependent inhibition ifn-gamma signaling determine cd8+ t-cells contribute murine liver carcinomas cd4−/−cd8−/− versus wt rag2−/− versus rag2−/−cd4+ tumor regression induced exhibited delayed kinetics
Questions {❓}
- Breast cancer by proxy: can the microenvironment be both the cause and consequence?
- Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?
- The anticancer immune response: indispensable for therapeutic success?
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