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Title[redir]:
Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation - PMC
Description:
Epigenetic alterations have been increasingly implicated in oncogenesis. Analysis of Drosophila mutants suggests that Polycomb and SWI/SNF complexes can serve antagonistic developmental roles. However, the relevance of this relationship to human ...
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Keywords {🔍}
ezh, snf, doi, expression, inactivation, figure, genes, cell, pcg, gene, stem, mefs, cancer, snfdeficient, pubmed, google, scholar, tumor, cells, epigenetic, swisnf, control, pinka, pmc, loss, levels, tumors, article, formation, data, hkme, polycomb, cancers, free, complex, compared, roberts, cellassociated, proteins, primary, set, targets, chromatin, found, embryonic, proliferation, oncogenic, transformation, programs, lymphomas,
Topics {✒️}
cd4-cre expressing snf5fl/fl snf5fl/fl cd4-cre tumor-free survival curves cd8+ t-cells purified cd8+ t-cells compared pmc beta search peripheral t-cells rapidly cd8+ t-cell samples genome-wide chip-chip analyses peripheral t-cell numbers normal cd8+ t-cells mef-specific ezh2-regulated genes nf-kappab gene network murine snf5-deficient lymphomas snf5-deficient lymphomas compared swi/snf complexes mediate cd3 t-cell marker swi/snf complex represents mouse t-cell lineage covalent histone-tail modifications peripheral t-cell development swi/snf-brg1 regulates cd8+ t-cells snf5-deficient tumor cells genome-wide localization studies step cross-linking method snf5-deficient tumors constitute snf5-deficient mefs compared ink4b-arf-ink4a locus snf5-deficient rhabdoid tumors cd4-cre transgene experimental procedures snf5 double deficient mefs ezh2-deficient mefs compared supplementary materials included crossed snf5-conditional mice snf5-deficient cancer cells snf5-ezh2 doubly conditional proliferation-deficient stem cell peripheral t-cells ezh2fl/fl prevent high-level expression atp-dependent chromatin remodeling driving snf5-deficient tumors references ben-porath experimental genes represent swi/snf activity lead lineage-specific pcg targets wild type mouse a301-087a snf5 antibody
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