
NCBI . NLM . NIH . GOV {
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Title[redir]:
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis - PMC
Description:
In inflammatory bowel disease, the relationship between a host and gut microbial community goes awry. We have characterized the fecal microbial communities in a mouse IBD model driven by T-bet deficiency in the innate immune system. 16S rRNA-based ...
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Keywords {🔍}
mice, truc, doi, mirabilis, pneumoniae, colitis, rag, fig, fecal, pubmed, google, scholar, weeks, klebsiella, host, microbiota, microbial, tnfα, pmc, bacterial, proteus, cell, article, free, tbet, cells, age, gut, levels, garrett, disease, community, analysis, time, communities, inflammation, enterobacteriaceae, inflammatory, immune, treatment, species, mouse, ibd, shown, bacteria, intestinal, samples, animals, observed, control,
Topics {✒️}
anti-tnf-α neutralization accounted hamster anti-gst igg1 fluor-conjugated 16s rrna transcription factor t-bet t-reg infusion ameloriated 16s rrna-based analyses curative anti-tnf-α 16s rrna-based analysis tnf-α blockade disclosed sherlock gc-fame platform germ-free status confirmed pmc beta search �bacterial-free zone’ adjacent t-regulatory cell infusion suction-powered milking apparatus generate pro-inflammatory responses hddc germ-free core anti-tnf-α mice pro-inflammatory cytokine profile gamma-irradiation induced activation trigger pro-inflammatory responses error-correcting barcode incorporated �universal’ bacterial probe-eub338 tnf-α blockade experiment germ-free truc mice dextran sulfate sodium attributable tnf-α sequestration 16s rrna-defined communities error-correcting barcoded primers cd11c+ dendritic cells tnf-α neutralizing antibodies identify cell-based mechanisms experimental procedures husbandry neonatal cross-fostering experiments elevated tnf-α levels host-mediated inflammation disrupts initial culture-based screen lower tnf-α levels t-reg infusion gram-negative aerobes present approximately-maximum-likelihood implementation vitro mono-culture conditions t-bet−/− × rag2−/− commensal-specific secretory iga host pro-inflammatory response t-bet deficiency anti-tnf-α t-regulatory cells references buescher es pathogen-free wt
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