
NCBI . NLM . NIH . GOV {
}
Title[redir]:
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment - PMC
Description:
Development of effective and durable breast cancer treatment strategies requires a mechanistic understanding of the influence of the microenvironment on response. Previous work has shown that cellular signaling pathways and cell morphology are ...
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Keywords {๐}
cells, cell, doi, cancer, breast, culture, pubmed, google, scholar, trastuzumab, signaling, skbr, lines, pmc, integrin, article, response, lapatinib, lrecm, cultures, bissell, free, fig, treatment, pertuzumab, aiib, hcc, proliferation, mammary, conditions, agents, grown, growth, activation, downstream, tissue, biol, hertargeting, ยตgml, threedimensional, heramplified, significantly, drug, human, brdu, line, berkeley, national, inhibition, data,
Topics {โ๏ธ}
engelbreth-holm-swarm tumor matrix her2-amplified cell lines supplementary material ice-cold pbs/edta [6] growth factor receptors 5-bromo-2โฒ-deoxy-uridine labeling pmc beta search pten-inactivating gene mutation beta4 integrin-dependent formation anti-her2 tailored therapy regulates cell growth human breast cancer ras-mapk-signaling cascades supplementary materials included her2-amplified bt549 cells laminin-rich ecm tyrosine kinase domain ras-mapk-pathway activation monoclonal antibody inhibiting single anti-her2 agents specific rat igg1 human breast cells her2-targeting agents trastuzumab her2-targeting drugs trastuzumab methods cell culture cell lines studied cell lines lacking provide biochemical signals mammary tumor growth nat rev cancer primary mammary cultures human cancer cells license information pmcid downstream signaling cascade adenovirus receptor cell signaling technology induce acinar polarity bt549 cell line ฮฒ1 integrin subunit signaling pathways downstream breast cancer initiation rapidly distinguish growth her2 downstream signaling pten-inactivating mutation showed enhanced phosphorylation breast epithelial function dimensional cell culture biochem cell biol humanized monoclonal antibodies breast cancer cells
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Analytics and Tracking {๐}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {๐}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {๐ฆ}
- Ncbi