NCBI . NLM . NIH . GOV {
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Title[redir]:
ER Stress Controls Iron Metabolism Through Induction of Hepcidin - PMC
Description:
Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin overproduction causes anemia of inflammation, whereas its deficiency leads to hemochromatosis. Inflammation and iron are known extracellular ...
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Keywords {🔍}
hepcidin, crebh, doi, fig, iron, expression, promoter, stress, data, google, scholar, mice, pubmed, response, cells, hepg, mrna, hamp, protein, activity, control, site, pmc, homeostasis, treated, nlm, cell, xbp, experiments, wildtype, blood, science, activation, gene, hepatic, ncbi, search, form, liver, inflammation, transcription, factors, lps, shown, vitro, lower, analyzed, sirna, transfected, induction,
Topics {✒️}
org/cgi/content/full/325/5942/877/dc1 materials 129s6/svevtac wild-type mice primary anti-microbial strategy acute-phase response genes stress-related transcription factors er stress–induced factors anti-crebh antibody relative hamp promoter fragment pmc beta search specific anti-crebh antibody supplementary materials included basal luciferase activity liver-specific transcription factor induces hepcidin expression wild-type mhamp-775/+14-luc liver-specific albumin mrna iron-regulatory hormone hepcidin decrease promoter activity mutated mhamp-775/+14-luc plasmids exogenously administered toxins regulate gene transcription acute-phase protein luciferase activity assessed hepcidin promoter activity hamp promoter reporter nih grants dk42394 mhamp-775/+14-luc plasmid increased hepcidin mrna mutant promoter constructs hepatic hepcidin expression endogenous hamp mrna regulated hepcidin expression dominant negative anti-crebh antibody pgl3-basic plasmid hepatic hepcidin mrna regulated hepcidin mrna spleen ferroportin expression hepcidin promoter segments ethidium bromide stain severe er stress stimulate hepcidin expression acute inflammatory response c-reactive protein er stress links united states government license information pmcid central humoral mediator characterized signaling pathways extremely high requirement
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