
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells - PMC
Description:
Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as “mammospheres” in ...
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Keywords {🔍}
cells, msc, doi, breast, cancer, cell, ecadherin, mcf, mammosphere, mdaibc, formation, tumor, expression, figure, mammospheres, stem, pubmed, tumors, google, scholar, msccm, sum, human, hmec, spheres, increase, increased, mesenchymal, data, growth, gfp, cultured, days, pmc, mammary, culture, derived, media, normal, lines, protein, plated, vivo, article, epithelial, xenografts, analysis, tif, promote, tic,
Topics {✒️}
fifty-percent msc-cm resulted pro-invasive n-cadherin protein assess gfp+cd44+cd24− cells dominant negative e-cadherin human breast cancer—observations serum-free mammosphere culture e-cadherin positive clusters cd44+cd24− mda-ibc-3 cells serum-free mem supplemented express detectable n-cadherin promote epithelial-mesenchymal transition pro-invasive mesenchymal phenotype serum-free msc-cm pmc beta search ultra-low attachment plates altering e-cadherin expression persistent e-cadherin expression scid/beige immunocompromised mice mda-ibc-3 cell lines mda-ibc-3 cell line inflammatory line mda-ibc-3 e-cadherin promotes metastasis detect e-cadherin protein decrease e-cadherin expression α-minimum essential medium demonstrate multi-lineage potential supplemental table s1 decreased e-cadherin expression serum-free conditions stem cells markers low-density suspension cultures sphere-promoting factor gfp+ mda-ibc-3 cells gfp+cd44+cd24− cells express n-cadherin reduce emt-induced migration lower e-cadherin expression mda-ibc-3 tumor cells mammary stem cells anderson cancer center e-cadherin positive human embryonic lung mesenchymal stem cell expressing cells contained license information pmcid epithelial-mesenchymal transition inflammatory breast cancer conditioned media derived promote hormone independence injected mda-ibc-3 xenograft
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